Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Let's do something amazing together!
The Manager, Sales Operations will play an important role in the commercial success of Arrowhead's leading investigational cardiometabolic medicine — Redemplo (siRNA targeting APOC3). This product has demonstrated compelling clinical data to date, has been approved by the FDA for Familial Chylomicronemia Syndrome (FCS), and is in late-stage development for other grievous conditions, including Severe Hypertriglyceridemia (SHTG). Over time, this role will expand to cover additional indications and products across the Arrowhead portfolio.
We're looking for someone who thrives in ambiguity and enjoys building. This function is still taking shape; you'll have real latitude to define process, systems, and best practice rather than inherit a fully built playbook.
In this role, you will support Sales Operations for our field-based teams, reporting to the Director of Commercial Operations and working closely with Sales and Marketing leadership. You'll help translate commercial strategy into concrete plans and goals for the field, support sizing, targeting, and incentive compensation. You’ll also help build and optimize the systems (CRM, data infrastructure) that make field execution possible.
Responsibilities
Field Excellence
- Help set national and regional sales targets in compliance with regulations and in alignment with forecasts. Help align targeting and call planning with business strategy.
- Support the implementation and management of sales compensation plans and incentive programs, adjusting as needed to optimize performance, and help automate targeting and incentive processes.
- Help manage field alignment, workload calculation, and territory mapping, adjusting as needed to optimize performance and collaborating with sales leadership on field resource allocation.
Build Infrastructure and Improve Process
- Partner with IT to support management of the data underlying sales and marketing operations including targeting, incentive compensation, KPIs, field sizing, and reporting. Maintain customer master data and optimize data sources for field sales planning.
- Drive ongoing improvement of the CRM and related sales systems.
- Support Commercial Operations budget tracking and manage day-to-day vendor coordination and relationships.
- Manage the field fleet program: vehicle assignments, lease schedules and renewals, fleet vendor relationships, policy compliance, and serve as the field's point of contact for fleet needs.
Create Insights
- Support the definition, development, and regular communication of business KPIs and metrics to commercial stakeholders.
- Partner with commercial leadership and business analytics to track and report on KPIs, turning data into insight that shapes field strategy.
Requirements
- Bachelor's degree in a business-related or life sciences field.
- Strong understanding of the life sciences industry.
- 5+ years of experience spanning sales, analytics, and sales operations
- Demonstrated experience building processes, systems, or infrastructure from the ground up, ideally in ambiguous or fast-changing environments (startup, early-stage commercial launch, new business line, or similar).
- Strong quantitative and analytical skills, with comfort in data modeling, CRM/BI tools, and translating data into clear, actionable recommendations for commercial leadership.
- Strong organizational and time management skills; comfortable operating in a matrixed, team-based environment.
- You may be required to travel for up to 20% of your time.
Preferred
- Pharmaceutical or biotech experience strongly preferred, but candidates from other industries (consulting, tech, med device, etc.) with strong analytical and operational rigor are encouraged to apply.
- Experience in the cardiometabolic disease space
- Management consulting experience
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Skills Required
- Bachelor's degree in business-related or life sciences field
- 5+ years of progressive commercial experience in biotechnology or pharmaceuticals
- 2+ years of pharmaceutical data/sales operations experience (brand management, data management, sales operations, analytics, forecasting)
- Strong leadership and communication skills
- Effective vendor management experience
- Ability to work collaboratively in a matrixed, team-based environment with strong organizational and time management capabilities
- Willingness/ability to travel up to 20%
- Current, valid authorization to work in the country where this role is located
- Experience in the cardiometabolic disease space
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
