Machine Learning Application Engineer II

At Maze Therapeutics, we believe precision medicine has the power to transform the lives of patients with both common and rare diseases. As a Machine Learning Application Engineer II, you will play a hands‑on role in delivering high‑impact, production‑grade solutions that advance our drug discovery programs. You will design, build, and scale data and machine learning infrastructure across early research, lead optimization, and development stages of the drug discovery pipeline. In this role, you will enable data‑driven science while upholding strong engineering standards and FAIR data principles. 

This position reports to a Senior Data Engineer. 

• Support management of biobank scale datasets in Polaris, Maze’s internal platform supporting Compass, by building scalable data ingestion, cleaning, processing, and validation pipelines. 
• Work with scientific compute teams to design and deploy machine learning models to support workflows in research and small molecule drug discovery (compound property prediction, assay data prediction, data analysis). 
• Lead the evaluation and integration of Large Language Models (LLMs) to automate data ingestion workflows, enhance intelligent querying, and support user-facing variant association and scientific visualization platforms. 
• Design and operate scalable ML and data platforms leveraging Terraform (IaC) and Git-based CI/CD pipelines, incorporating workflow orchestration, automated model lifecycle management, and production-grade monitoring and reliability. 
• Collaborate with development organization to evaluate and deploy ML tools that support workflows across Regulatory, Clinical Operations, and Medical Affairs. 
• Collaborate cross-functionally translate scientific requirements into production-grade systems. 

• Master’s degree in Computer Science, Machine Learning, Bioinformatics, Data Engineering, or related fields. 
• 3+ years of industry experience building production-grade data and ML pipelines, preferably in life sciences supporting drug discovery. 
• Hands-on experience deploying AI/ML models in drug discovery applications (e.g., computational biology/chemistry workflows). 
• Experience with FAIR data principles and strong programming skills in Python and SQL (R is a plus). 
• Proven experience in deploying and maintaining ML systems, including CI/CD, workflow orchestration, and monitoring. 
• Experience with workflow orchestration tools (e.g., Airflow, Prefect). 
• Experience with containerization and cloud infrastructure (Docker, Kubernetes, AWS or similar). 

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease.  Maze is based in South San Francisco.

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $154,000 - $188,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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