*****This Position is On-site in our Santa Fe, NM Office*****
OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. OpenEye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.; Cologne, Germany; and Tokyo, Japan.
We are looking for a lead scientific software developer to join a growing team of experts working on biologics and protein design. The highly focused team will work together to drive forward technologies which leverage AI and OpenEye’s long standing 3D modeling capabilities in our cloud platform, Orion. The team’s guiding principle is to deliver solutions that better enable scientists in the pharmaceutical and biotech industries to develop next generation biologic medicines.
*****This Position is On-site in our Santa Fe, NM Office*****
What you’ll do:
- Work on challenging problems and help find practical solutions that advance the field of computational biologics drug discovery
- Develop highly scalable and integrated solutions for biologics drug discovery in the cloud
- Develop data-driven models using sequence and 3D molecular shape representations leveraging AI and physics-based approaches
- Expand OpenEye’s biomolecular modeling and protein informatics technologies
- Collaborate with great colleagues within our group, within OpenEye & Cadence, as well as within the broader pharmaceutical industry on developing new methods, tools, and solutions
What you should have:
- *****This Position is On-site in our Santa Fe, NM Office*****
- PhD (or equivalent experience) in computational chemistry, structural biology, biochemistry, or related field with a least 5 years relevant experience
- Strong desire to change the field of biologics drug discovery through hard work, creating robust software tools, and critical scientific evaluation.
- Demonstrated ability to work both independently and as part of a team. Ability to work humbly with others, admitting mistakes and constructively working through differences in opinion.
- Experience with molecular dynamics simulations and machine learning
- Programming expertise, ideally in Python, preferably with experience using AI coding agents
- Proven track record of delivering software solutions
The following are a PLUS, but not required:
- Expertise with traditional machine learning and/or modern deep learning methods
- Experience with OpenEye software/toolkits or other computational chemistry toolkits
- Experience with protein language models and protein folding technologies
- Experience with modeling antibodies based on sequence and structural data
Skills Required
- PhD in computational chemistry, structural biology, biochemistry, or related field
- At least 5 years relevant experience
- Experience with molecular dynamics simulations and machine learning
- Programming expertise in Python
- Proven track record of delivering software solutions
Cadence Design Systems Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Cadence Design Systems and has not been reviewed or approved by Cadence Design Systems.
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Equity Value & Accessibility — A discounted ESPP with a lookback feature and equity included in total compensation make ownership broadly accessible and potentially meaningful. Structured compensation at an industry leader adds predictability to equity participation.
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Healthcare Strength — Medical, dental, and vision coverage are described as solid, with mental‑health/EAP and fertility support enhancing the offering. The breadth across core care and family‑building needs strengthens the healthcare package.
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Leave & Time Off Breadth — Global Recharge Days, volunteer time off, and companywide breaks indicate a comprehensive time‑off framework. In addition, many salaried roles are described as having flexible or generous PTO policies.
Cadence Design Systems Insights
What We Do
Cadence enables electronic systems and semiconductor companies to create the innovative end products that are transforming the way people live, work and play. Cadence® software, hardware and IP are used by customers to deliver products to market faster. The company's Intelligent System Design strategy helps customers develop differentiated products—from chips to boards to intelligent systems—in mobile, consumer, cloud, data center, automotive, aerospace, IoT, industrial and other market segments. Cadence is listed as one of Fortune Magazine's 100 Best Companies to Work For.
