Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The IT Infrastructure Manager will be responsible for the entire lifecycle (designing, planning, purchasing, implementing, maintaining, retiring) of IT infrastructure for Arrowhead across multiple sites. This includes physical, virtual, on premise and cloud-based assets used in the support of all functions of the business. This is a position where the candidate will be required to actively participate in and lead the day-to-day responsibilities to support the IT infrastructure. The candidate must have the ability to work on individual responsibilities and lead a team with minimal supervision in a fast paced, demanding environment.
Responsibilities
- Oversee all IT infrastructure including software, hardware, servers, and networks
- Design and implement strategic plans to ensure the IT infrastructure supports the company’s needs and future growth.
- Extensive experience implementing, managing, upgrading and maintaining virtualized environments using a variety of hypervisors (VMware, Nutanix, Hyper-V)
- Deploy and manage physical and virtual servers in various roles both on prem and cloud based
- Extensive knowledge and experience working in a Windows domain environment deploying and managing a wide variety of servers including AD, DNS, DHCP, NPS, WSUS, File and Print
- Architect, implement and maintain companywide storage solutions both on prem (SAN/NAS) and cloud based
- Design, implement and maintain Azure and AWS compute and storage solutions to meet business needs
- Perform regular backup operations and implement appropriate processes for data protection, disaster recovery, and failover procedures that meet established RTO and RPO standards
- In depth Group Policy experience
- Patch Windows endpoints via WSUS and/or third-party tools
- Project management experience
- Manage employees/contractors/service providers involved in supporting all IT Infrastructure
- Basic LAN/WAN/SDWAN network management
- Develop and manage IT policies and procedures
- Monitor system performance and troubleshooting issues
- Ensure data is handled, transferred or processed according to legal and company guidelines
- Manage IT infrastructure budget
- Coordinate IT activities to ensure data availability and network services with as little downtime as necessary
- Manage vendor relationships and contracts
- Keep abreast of the latest IT trends and technologies to drive innovation
Requirements
- Bachelor’s degree in computer science or life sciences, other related field, or equivalent experience
- 5+ years experience working in a systems administrator or infrastructure management role.
- Proven experience as an IT Infrastructure Manager, IT Manager or similar role
- Experience in analysis, implementation, and evaluation of IT systems and their specifications
- Experience in controlling information technology budget
- Sound understanding of computer systems (hardware/software), networks etc.
- Excellent organizational and leadership skills
- Outstanding communication skills
- Excellent problem-solving skills
Preferred:
- Excellent experience with pharmaceutical/CRO industry regulations, standards, and guidelines (GxP, CSV/CSA validation, 21 CFR Part 11, EU Annex 11, SDLC)
- Pharmaceutical or CRO experience
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients.
Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety.
Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline.
Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations.
Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
