Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
The Biophysics and Protein Sciences Group generates target proteins to support drug discovery efforts. We currently utilize heterologous overexpression systems, including bacterial and insect cell expression, and purify proteins using a variety of approaches (e.g., bulk purification, FPLC, immunoprecipitation). To maximize our capacity to test multiple construct designs and rapidly determine which proteins can be reliably produced, we are actively developing a small-scale expression and purification (SmScExpPur) platform along with a series of protocols spanning the full workflow: from construct design through small-scale expression testing, purification, and quality control. The summer intern will contribute to this ongoing effort by owning a defined set of experiments aimed at further developing and evaluating SmScExpPur protocols, with the goal of improving protein yield, consistency, and quality. This will include executing small-scale expression and purification experiments, analyzing outcomes across constructs and conditions, and contributing data-driven recommendations for protocol improvements. Proteins generated through this work will be used to perform basic QC assessments to evaluate protein identity, aggregation state, and folding.
Required Skills, Experience and Education:
Prior hands-on laboratory experience in an academic or industry setting.
Strong attention to detail and experimental rigor.
Clear written and verbal communication skills.
Experience with basic laboratory techniques, including pipetting.
Experience documenting experiments through protocols, laboratory notebooks, laboratory reports, or research papers.
Familiarity with bacterial transformation and/or recombinant protein expression workflows.
Preferred Skills:
Experience with insect cell expression systems.
Experience with protein purification techniques (e.g., affinity purification, FPLC).
Interest or experience in protocol development, optimization, or troubleshooting.
Experience with liquid handling or semi-automated laboratory systems.
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The base pay salary range for this intern position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.
Please note that base pay salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.
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What We Do
We are Revolutionaries – passionate in our singular pursuit of discovering, developing and delivering innovative, targeted medicines for patients living with cancer. To deliver on our vision, we work relentlessly in pursuit of cutting-edge therapeutic approaches to some of the toughest cancers. Our current focus is on RAS-addicted cancers, which account for 30 percent of all new human cancer diagnoses
