High-Throughput Synthesis Scientist

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Overview: 

The High-Throughput Synthesis Scientist will design and execute automated parallel synthesis experiments. This role involves collaborating with Medicinal Chemists and DEL scientists to optimize and validate chemical routes for transfer to parallel synthesis platforms using both solution phase and solid phase chemistry approaches. The scientist will also contribute to the design, development, optimization, validation, and integration of complex automation systems for high-throughput automated synthesis. An active presence in the laboratory and a ‘can-do’ attitude are essential. 

Key Responsibilities: 

• Design and synthesize chemical arrays using automated synthesis platforms. 

• Develop new methodologies for solid phase parallel automated synthesis. 

• Participate in daily operations and maintenance of various automated equipment. 

• Collaborate with medicinal chemistry teams and DEL scientists to leverage automated chemistry capabilities for advancing discovery programs. 

• Contribute to scientific strategies and goals within a project team setting. 

Requirements: 

• Doctorate degree with 2 years of medicinal chemistry or pharmaceutical research experience, OR 

• Master's degree with 5 years of medicinal chemistry or pharmaceutical research experience, OR 

• Bachelor's degree with 7 years of medicinal chemistry or pharmaceutical research experience. 

Required Skills and Experience: 

• Expertise in applying parallel synthesis techniques to synthetic and medicinal chemistry. 

• Ability to work in a cross-functional environment with a proactive mindset to enhance productivity and efficiency. 

• Proficiency in operating, maintaining, and troubleshooting high-throughput synthesis systems. 

• Excellent organizational and communication skills, coupled with strong analytical and problem-solving abilities. 

• Working knowledge of solid phase synthesis and solution phase synthesis with solid supported reagents. 

Preferred Skills and Experience: 

• Proficiency in utilizing automation systems for high-throughput applications within pharmaceutical, biotech, or related industries. 

• Experience with operating and programming liquid handling robotics platforms. 

• Familiarity with modern cheminformatics tools, computational tools, enumeration tools, and other scientific software for drug discovery. 

• Practical knowledge of medicinal chemistry principles. 

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