Executive Director, Head of Global Site Management

Role Summary 

The Head of Global Site Management leads all site-facing clinical trial activities across the global development portfolio.  This operational leadership role is responsible for Site Management & Monitoring and Clinical Trial Optimization & Strategic Partnership functions.  This role provides strategic leadership for site start-up, site management, and monitoring to drive predictable execution, accelerate timelines, improve enrollment performance, ensure high-quality data, and establish strategic site partnerships. 

As a member of the Clinical Operations senior leadership team, this role is also responsible for supporting strategic initiatives across the development organization. 

Key Responsibilities 

• Build & lead global site management, monitoring, and study start-up activities across all clinical programs 

• Develop and execute site strategies to optimize selection, activation, enrollment, and retention 

• Establish consistent monitoring models, including risk-based monitoring approaches 

• Build and maintain strategic relationships with investigative sites, site networks, and partners 

• Partner closely with Clinical Operations, Clinical Development, Biometrics, and Development Services to ensure seamless, disciplined program and trial execution 

• Identify and mitigate site-level operational and quality risks 

• Establish scalable processes, metrics, and dashboards to track and improve site performance 

• Establish operating model inclusive of vendor strategy, oversight, risk management, key performance metrics, and dashboards 

• Provide expert insight into operational strategy plans (feasibility, monitoring strategies) and operating budgets 

• Create and continuously improve standard operating procedures, work instructions, to ensure inspection readiness 

• Participate in regulatory authority inspections, sponsor audits, and oversee site audits in partnership with Quality 

• Ensure compliance with GCP, regulatory requirements, and internal standards 

• Ability to assess and transform capabilities through AI and Automation solutions or strategies 

• Up to 20-30% domestic and international travel, as required. 

Qualifications 

• Bachelor's degree in life sciences or related field  

• 12+ years of experience in site management or clinical operations leadership  

          Or advanced degree (PhD, MBA, Masters) and 10+ yrs of experience 

• Deep expertise in global study start-up and enrollment optimization 

• Strong people leadership and stakeholder management skills