Heartflow is a medical technology company advancing the diagnosis and management of coronary artery disease, the #1 cause of death worldwide, using cutting-edge technology. The flagship product—an AI-driven, non-invasive cardiac test supported by the ACC/AHA Chest Pain Guidelines called the Heartflow FFRCT Analysis—provides a color-coded, 3D model of a patient’s coronary arteries indicating the impact blockages have on blood flow to the heart. Heartflow is the first AI-driven non-invasive integrated heart care solution across the CCTA pathway that helps clinicians identify stenoses in the coronary arteries (RoadMap™Analysis), assess coronary blood flow (FFRCT Analysis), and characterize and quantify coronary atherosclerosis (Plaque Analysis). Our pipeline of products is growing and so is our team; join us in helping to revolutionize precision heartcare.
Heartflow is a publicly traded company (HTFL) that has received international recognition for exceptional strides in healthcare innovation, is supported by medical societies around the world, cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 500,000 patients worldwide.
About the role
To accelerate this mission, we are seeking an Engineering Manager to build and lead our new Agentic AI initiatives team.
This is a unique "player-coach" opportunity. You will start in a deeply hands-on capacity - acting as the lead architect and foundational engineer to set up the core ecosystem that allows autonomous, intelligent agents to execute multi-step medical reasoning securely and at scale. As the foundation is laid and the product gains momentum, your role will transition into a full Engineering Manager capacity. You will be responsible for scaling a world-class team of engineers, guiding their execution, and shaping the long-term technical strategy of the platform.
You will have a true blank-canvas opportunity to design production-grade agentic systems from scratch, directly translating our decade-plus of clinical AI success into the next generation of autonomous medical technology.
Job Responsibilities
- Initial Hands-On Execution: Design, architect, and write code for a robust, secure, and scalable Agentic AI platform, establishing standard patterns for multi-agent orchestration, state management, tool usage, and memory.
- Team Building & Leadership: Transition from an individual contributor/architect role into a dedicated management role as the team scales.
- Technical Strategy: Drive the technical execution of brand-new, agent-driven product features from initial ideation to production deployment. Build systems to parse requirements, map software modules, and auto-generate test cases.
- Safety & Compliance: Implement advanced guardrails, evaluation frameworks, and reasoning validation loops to ensure agent behaviors are safe, deterministic, highly accurate, and meet the compliance rigor required for FDA-cleared software.
- Cross-Functional Collaboration: Work closely with product managers, clinical experts, and data scientists to translate clinical needs into technical AI agent architectures and viable product roadmaps.
- Best Practices: Champion software engineering best practices (CI/CD, comprehensive testing, logging for non-deterministic systems) and keep the team ahead of the rapidly evolving AI landscape.
Required Qualifications
- 8+ years of professional software engineering experience, with a proven track record of shipping production-grade software.
- 5+ years of experience managing, mentoring, or acting as a formal technical lead for software engineering teams.
- Player-Coach Mentality: Willingness and technical capability to be deeply hands-on with code and architecture during the first 6–12 months while concurrently building the team.
- Deep, hands-on experience building applications with Large Language Models (LLMs) and a strong understanding of agentic architectures, orchestration frameworks, and vector databases.
- Advanced proficiency in Python or Go, alongside a solid grasp of microservices, API design, and cloud infrastructure (AWS or GCP).
- A passion for greenfield projects - you thrive in ambiguity, enjoy designing systems from scratch, and love solving complex, open-ended problems.
Nice-to-Have
- Experience deploying AI applications in regulated industries (Healthcare, Finance, etc.) or navigating HIPAA/GDPR compliance.
- Active contributions to open-source LLM or Agentic AI frameworks.
- Experience with advanced prompt engineering, fine-tuning, or RAG optimization.
A reasonable estimate of the base salary compensation range is $200,000 to $270,000, cash bonus, and equity. #LI-IB1 #LI-Hybrid
Skills Required
- 8+ years of professional software engineering experience with a proven record of shipping production-grade software
- 5+ years managing, mentoring, or serving as a formal technical lead for software engineering teams
- Ability and willingness to remain deeply hands-on with code and architecture for the first 6–12 months while building the team
- Hands-on experience building applications with LLMs
- Strong understanding of agentic architectures, orchestration frameworks, and vector databases
- Advanced proficiency in Python or Go
- Understanding of microservices, API design, and cloud infrastructure using AWS or GCP
- Experience deploying AI applications in regulated industries or navigating HIPAA/GDPR compliance
- Active contributions to open-source LLM or Agentic AI frameworks
- Experience with advanced prompt engineering, fine-tuning, or RAG optimization
What We Do
Heartflow is the global leader in AI-driven coronary artery disease (CAD) management, transforming how CAD — the world’s leading cause of death — is diagnosed and treated. Our advanced technology generates personalized, precision 3D heart models from a single CT scan, providing clinicians with the clarity and confidence to deliver earlier, more effective treatments — transforming CAD into a disease that can be managed for life. Heartflow One is the only complete, non-invasive, precision coronary care platform providing patient insights throughout the guideline-directed CCTA pathway. The AI-driven platform — including Roadmap™ Analysis, FFRCT Analysis and Plaque Analysis — is supported by the ACC/AHA Chest Pain Guideline and backed by more than 600 peer-reviewed publications. With over 400,000 patients treated, more than 1,400 leading institutions adopting our solution, and 99.5% of U.S. lives covered — Heartflow is redefining the standard of coronary care. We're a global company, with employees across the United States, Europe and Japan. Our headquarters are in Mountain View, California, with additional offices in California, Texas, the UK, and Japan. We believe CAD shouldn’t be a silent threat. By making it screenable, diagnosable, and manageable, we’re changing the story of CAD, empowering clinicians to save lives and giving patients more time for what matters most.
Why Work With Us
Join Us to Rewrite the Story of CAD.
