PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.
Position Summary:
The Instrument Engineering team is seeking a highly motivated and detail-oriented NPI Mechanical Engineer II to support new product introduction (NPI), production, and product ramp-up activities. In this role, you will help bridge the transition from design to manufacturing, ensuring new instrument products are introduced efficiently, cost-effectively, and to the highest quality standards.
You will work closely with R&D, Manufacturing, Quality, Supply Chain, and Contract Manufacturing partners to define processes, resolve technical challenges, and continuously improve product performance and manufacturability. This position offers the opportunity to work on complex, high-impact instrumentation that advances PacBio’s mission of enabling the promise of genomics.
Responsibilities:
- Lead and execute NPI activities to ensure seamless product transitions from R&D to full-scale manufacturing.
- Support instrument and sub-assembly builds, troubleshooting, and root cause analysis to improve yield and reliability.
- Create, review, and release detailed engineering drawings, specifications, and BOM structures.
- Design, validate, and document packaging for instruments and spare parts to meet quality and compliance standards.
- Develop and implement scalable manufacturing processes and process control documentation.
- Collaborate with Contract Manufacturing partners on training, issue resolution, and ongoing quality improvements.
- Drive mechanical design, prototyping, integration, testing, and final product release activities.
Required Qualifications:
- Bachelor’s degree in Mechanical Engineering.
- A minimum of 4–6 years of relevant industry experience in mechanical design, manufacturing engineering, or new product introduction.
- Proven hands-on experience in equipment assembly and/or hardware repair.
- Ability to work independently with minimal supervision.
- Excellent interpersonal, written, and verbal communication skills.
- Excellent documentation skills with attention to detail and quality.
- Results-driven mindset with a demonstrated desire to grow into roles with greater responsibility.
This role is required to be onsite Monday-Friday.
Candidates must have current authorization to work in the United States without the need for present or future sponsorship.
You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.
All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
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Salary Range:
$97,400.00 - $146,200.00To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or [email protected] for assistance.
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What We Do
At PacBio, we’re devoted to empowering you. Pioneering the future through biology takes vision. You have to look beyond the status quo to what’s possible.
We know your vision can reveal the full potential of the genome, advance human health and the health of our planet. And that is why your vision and pursuit are at the very center of what our company does — our product design, our customer support model, our partnerships, and even our identity.
We create the world’s most advanced sequencing systems to provide you the most complete and accurate view of genomes, transcriptomes, and epigenomes. Our founders invented a new way to study the synthesis and regulation of DNA, RNA, and proteins. Driven by a desire to advance human health, we’re harnessing advances in biochemistry, optics, nanofabrication, and more.
We are passionate about developing products that empower scientists to explore the full spectrum of genetic variation in any organism — from unraveling the mystery of rare diseases to improving the world’s food supply. With world-class service and support, we keep your research progressing so you can focus on finding answers.
We encourage you to see the whole picture — and consider us the partner you trust to see it too.
