Senior Director, Antibody Discovery and Engineering

Who We Are:
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

We are seeking a highly experienced individual for a position as Senior Director, Antibody Discovery and Engineering. This position will oversee CROs responsible for designing, generating, and characterizing antibody-based therapeutics, including multispecifics and other advanced modalities and may head a small team of scientists. The position will report to the Head of Discovery Technologies and work closely with scientists and leaders in Computational Sciences, Protein Sciences, Assay groups and interact with project teams. The position requires the candidate to have extensive experience in antibody discovery, engineering, characterization, rational design/combinatorial approaches, and computational engineering. 

Position Requirements:

• Ph.D. in molecular biology, biochemistry, or related discipline, plus >15 years of experience working in academic or biopharma/biotech sectors
• Extensive experience in antibody discovery both in vivo and in vitro approaches 
• Proficient with various protein display systems such as yeast, bacteria, phage and mRNA display
• Skilled in library creation, selection, and enrichment analysis
• Experience using evolutionary approaches to optimize protein function and rational design of proteins
• Working knowledge of current AI/ML approaches for protein structure and interaction predictions in the context of antibody development
• Experience in managing and leading CROs
• Accountable, meticulous with attention to detail, and able to multitask
• Prior experience leading an equivalent organization is strongly preferred
• Strong teamwork and proactive communication skills
• Self-motivated and able to work independently in a cross-functional team environment
• Must be willing to work onsite 5 days a week

The estimated base salary range for this role is $314,000 - $332,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.