Senior Director, R&D Strategic Sourcing and Procurement

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Senior Director, R&D Strategic Sourcing & Procurement

Overview:

The Senior Director of R&D Strategic Sourcing & Procurement is a strategic leadership role responsible for developing and executing sourcing and procurement strategies that support the organization’s research, nonclinical, regulatory, pharmacovigilance, and broader development objectives. This includes ensuring access to high-quality scientific services and external partners required across the full R&D value chain — from early discovery through late-stage development and post-marketing safety operations.

This leader combines sourcing expertise with a strong understanding of scientific, regulatory, and safety operations, including CROs, CDMOs, regulatory consultancies, pharmacovigilance service providers, and technology platforms supporting R&D programs. The role collaborates closely with R&D, Regulatory Affairs, Safety/PV, Quality, Legal, and Finance to optimize spend, manage risk, enhance supplier performance, and enable innovation across the scientific and regulatory supply base.  The position also leads development of vendor governance frameworks, contracting standards, and compliance controls to ensure alignment with GxP expectations, corporate policies, and audit readiness.

Responsibilities:

Strategic Leadership:

• Develop and communicate the long-term vision, goals, and roadmap for R&D Strategic Sourcing & Procurement, ensuring alignment with scientific, regulatory, and portfolio development priorities.
• Lead category strategy development across key R&D and adjacent business areas, including:
  • Discovery and preclinical research services
  • CRO services
  • CDMO development services
  • Regulatory Affairs services
  • Pharmacovigilance outsourcing, safety databases, and safety monitoring services
  • Medical writing and scientific documentation services

• Partner with leaders across R&D, Regulatory Affairs, and Pharmacovigilance to anticipate evolving program needs and ensure sourcing strategies enable speed, compliance, and scientific excellence.

Supplier Relationship Management:

• Build, manage, and optimize strategic relationships with CROs, CDMOs, regulatory and safety service providers, scientific service firms, and software vendors.
• Ensure suppliers meet scientific, regulatory, safety reporting, quality, and delivery requirements across all stages of development.
• Lead and/or support negotiations for complex agreements (MSAs, SOWs, licensing contracts, PV service agreements, regulatory consulting contracts) to secure favorable terms, reduce risk, and support organizational objectives.
• Lead and facilitate Quarterly Business Reviews (QBRs) with strategic suppliers to monitor performance, assess risk, drive continuous improvement, and ensure alignment with program needs and organizational priorities.
• Partner with R&D, Regulatory, PV, Quality, Legal, and Finance to ensure supplier capabilities meet scientific, operational, and compliance expectations.

Strategic Sourcing & Procurement Excellence:

• Establish and maintain best-in-class sourcing methodologies, procurement policies, and governance frameworks across scientific, regulatory, and safety categories.
• Lead and manage large, complex RFPs and sourcing initiatives, including scope development, cross-functional alignment, supplier evaluation, proposal scoring, negotiation strategy, and final supplier selection.
• Drive sourcing initiatives that optimize costs, strengthen supplier performance, increase operational efficiency, and deliver value across R&D and regulatory functions.

Performance Management:

• Help define and track KPIs that measure sourcing and procurement performance, supplier reliability, regulatory/SOP adherence, and value creation across scientific and non-scientific categories.
• Conduct risk analyses, spend analytics, supplier evaluations, and market intelligence reviews to identify opportunities and mitigate potential gaps.
• Present insights, category strategies, and recommendations to R&D executives and corporate leadership to influence strategic decisions and budget optimization

Qualifications:

• Bachelor's degree in Scientific Discipline, Supply Chain Management, Business Administration, Engineering, or related field; advanced degree (MBA, MS, or equivalent) preferred.
• Minimum of 12 years of experience in strategic sourcing, procurement, or supply chain, with substantial experience supporting R&D, Regulatory Affairs, Pharmacovigilance, or Nonclinical Development in the biotech/pharma industry.
• Demonstrated success building and executing category strategies across complex scientific, regulatory, and safety service environments.
• Strong understanding of drug discovery, nonclinical development, global regulatory processes, and pharmacovigilance requirements (GLP, GCP, GVP, and broader GxP frameworks).
• Strong negotiation experience with CROs, CDMOs, regulatory consultancies, and safety service vendors.
• Proven ability to design, lead, and execute large and complex RFP processes in highly cross-functional environments.
• Exceptional communication, stakeholder management, and leadership skills, with the ability to influence at all organizational levels.
• Experience with procurement technology platforms, including Coupa, with the ability to leverage system capabilities to drive sourcing efficiency, spend visibility, and process optimization.
• Experience with ERP systems and scientific or regulatory SaaS platforms is highly desirable.
• Cross-category sourcing experience is a plus.

Requirements:

• Position will be based in West Conshohocken, PA and will require 3 days per week in the office.
• Travel requirements up to 20%, depending on program needs, supplier engagement, and regulatory/PV activities.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $248,000 - 299,000 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].