Director, Project Management

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Job Summary:

Madrigal Pharmaceuticals is seeking a results-oriented Director of Project Management to oversee the design, implementation, and operation of R&D program management tools & technology to enable efficient and effective development of work package templates, integrated project plans, program/study dashboards, and portfolio analytics.  Covering the full product lifecycle – from early development to post-marketing requirements – the Director will partner closely with program/project managers and clinical/functional leaders to build and maintain integrated project plans and ensure portfolio wide integration and visibility.  The Director will also have the opportunity to project manage non-clinical and early-stage clinical programs and studies.  Reporting to the Vice President of Project and Portfolio Management (PPM), this role will be instrumental in driving operational excellence and supporting the success of Madrigal’s development programs. 

Position Specific Responsibilities:

• Build Foundational Capabilities: Lead design, implementation, and operation of fit-for-purpose tools and technology to enable best-in-class project management of a growing, multi-asset portfolio
• Enable Project Planning: Support development and maintenance of detailed integrated project plans for full portfolio of R&D programs, studies, and/or projects, ensuring cross-enterprise alignment
• Mentor and Guide Teams: Serve as a trusted thought partner to program, study, and project teams, providing hands-on coaching, structure, and accountability within the project management disciple
• Ensure Project Delivery: Manage project timelines, deliverables, and budgets, proactively identifying and resolving risks or delays, escalating when appropriate
• Enable Strategic Decision-Making: Provide insights and analyses that inform trade-offs, prioritization, and investment decisions through development of detailed yet intuitive dashboards and analytics
• Influence Optimal Resourcing: Partner with VP, PPM to develop capacity models to anticipate resource needs, resolve gaps, and ensure effective allocation of talent and capabilities across portfolio
• Implement Best Practices: Promote project management standards, tools, dashboards, and processes that drive efficiency and continuous improvement within project teams
• Support Portfolio Review and Governance: Contribute operational support and content to project and portfolio reviews, governance bodies, and other forums as required
• Support R&D Initiatives: Partner with VP, PPM on cross-department initiatives, contributing project management and operational support as needed

Specialized Knowledge & Skills:

• Expertise in the development and implementation of foundational program management office tools, technology, and infrastructure
• Mastery of project management and dashboarding software (e.g., SmartSheet, Power BI, etc.)
• Demonstrated success in managing complex, cross-functional drug development program teams
• Understanding of drug development process from discovery through commercialization
• Strong ability to synthesize, distill, and succinctly communicate strategy, plan, and status for multiple complex, cross-functional initiatives to all audiences
• Experience in operating model, governance, and process design and implementation within R&D environments
• Excellent organizational and interpersonal skills, with a track record of leading and influencing cross-functional teams
• Outstanding written and verbal communication skills
• Self-motivated and able to multi-task within a fast-paced environment
• Comfortable with and skilled at navigating ambiguity
• Ability to lead and influence without authority
• Experience working in both small biotech and larger pharmaceutical company environments preferred
• Experience in metabolic or rare disease therapeutic areas preferred

Educational Requirements:

• Bachelor’s degree in scientific or relevant business discipline required.  Applicable advanced degree (e.g., MA, MBA, PhD, MD) a plus.

Experience:

• 12+ years of relevant experience including a minimum 10 years project management experience

Madrigal offers a competitive Total Rewards strategy to attract and retain top talent and is inclusive of base pay, bonus, equity, and a generous benefits package. Full-time employees are eligible for base salary, bonus, equity, and a comprehensive benefits suite.

Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs, and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $200,000 - $244,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].