Director, Process Engineering

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

Kymera is seeking a highly motivated and experienced Director of Process Engineering to provide strategic and technical leadership in small-molecule drug substance process development, scale-up, and commercial readiness for potentially transformational therapies for serious Immunology and Inflammation diseases. This is an opportunity to join a fast-paced, innovative biotech environment where bold ideas and collaboration drive breakthroughs. As a key member of the CMC organization, you will partner with process and analytical chemists to design robust, scalable, and cost-effective manufacturing processes that enable late stage development, manufacturing and eventual commercialization.

The ideal candidate will bring deep expertise in chemical process engineering within a GMP environment, strong project leadership capabilities, and a passion for working in a dynamic, mission-driven culture focused on delivering life-changing medicines.

Technical & Strategic Leadership

• Define and execute process engineering strategies aligned with Kymera’s timelines.
• Conduct design, development, optimization, and scale-up of small-molecule drug substance manufacturing processes using a unit operation approach.
• Drive process robustness, yield improvement, impurity control, and cost of goods optimization.
• Provide technical guidance for primarily outsourced development across various geographies.

CMC & Regulatory Support

• Co-lead registration stability, process characterization, and Process Performance Qualification (PPQ) activities.
• Co-author and review CMC sections of regulatory submissions (INDs, IMPDs, NDAs/MAAs), including process descriptions, control strategies, and validation approaches.
• Ensure processes are compliant with global regulatory expectations (FDA, EMA, ICH).
• Review and approve master and executed batch records.  Assist with deviations, change controls, and other QA related tasks.

 External Manufacturing & Partnerships

• Serve as the primary technical process engineering interface with C(D)MOs and external partners.
• Oversee and guide process development activities executed externally, ensuring timelines, quality, and technical rigor.

• Partner closely with Analytical Development, Drug Product Development, Quality, Regulatory Affairs, Supply Chain, and External CDMOs.

Operational Excellence

• Foster a culture of scientific excellence, accountability, and cross-functional collaboration.
• Implement best practices in process engineering, risk management, and data-driven decision-making.
• Identify and mitigate technical and operational risks from mid-stage development through commercialization.
• Contribute to long-range CMC planning, budgeting, and resource forecasting.

Education & Experience

• Ph.D., M.S., or B.S.  in Chemical Engineering.
• 15+ years of experience in small molecule pharmaceutical process engineering, with progressive technical and leadership responsibility.
• Demonstrated experience scaling small-molecule processes from theory to laboratory through commercial scale.
• Hands-on experience working with GMP manufacturing and CMOs.

Technical Expertise

• Strong understanding of chemical reaction engineering, unit operation modelling, crystallization, isolation, and purification processes.
• Experience with process modeling, scale-up principles, and technology transfer.
• Experience with process characterization- including Quality by Design (QbD) principles, process performance qualification (PPQ), and regulatory expectations for small molecules.
• Preference for candidates with a deep understanding of the principles of crystallization development and experience translating these to robust, scalable processes.

Leadership & Collaboration

• Proven ability to lead manufacturing and development activities and influence cross-functional stakeholders.
• Excellent communication skills, with the ability to clearly convey complex technical concepts.
• Comfortable operating in a fast-moving, entrepreneurial biotech environment.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.