Director, Portfolio & Program Strategy

The Role
Moderna is advancing its mRNA platform to unlock new therapeutic applications and expand its R&D portfolio across multiple disease areas. To maximize impact, the Portfolio & Program Strategy team plays a critical role in ensuring that portfolio investments are strategic, data-driven, and aligned with corporate priorities. This team operates across research, development and commercial functions to provide structured insights and enable executive decision-making.

The Director, Portfolio & Program Strategy, will be responsible for leading portfolio strategy projects and providing strategic investment recommendations. This individual will tackle Moderna’s most complex investment and prioritization questions, integrating scientific, financial, and strategic insights to drive high-impact decisions. As a strategic thought partner, they will ensure that portfolio and program strategies align with Moderna’s broader corporate objectives.

Here’s What You’ll Do

• Establish structured decision frameworks and processes to enable resource allocation, sequencing, and investment pacing based on real-time data and evolving priorities. 

• Partner with cross-functional teams (research, clinical development, commercial, manufacturing) to drive alignment on portfolio priorities, trade-offs, and strategic pivots.

• Assess the scientific, operational, and commercial impact of portfolio choices, ensuring enterprise-wide coordination while working closely with senior stakeholders. 

• Develop and refine portfolio models that integrate R&D attrition, clinical probability of success, commercial forecasts, and investment pacing to inform decision-making. 

• Deliver clear, data-driven insights and strategic recommendations to executive leadership, translating complex trade-offs into actionable, high-impact moves. 

• Continuously evaluate market, competitive, and internal pipeline dynamics to refine Moderna’s investment strategy.

Here’s What You’ll Need (Minimum Qualifications)

• 8+ years of experience in strategy, corporate development, or portfolio management within a clinical- or commercial-stage pharmaceutical/biotech company, or equivalent experience in management consulting (life-sciences focused), investment banking (healthcare sector) or venture capital (biotech/life sciences).

• Ability to perform and synthesize in-depth analyses of indications, products, and therapeutic areas, integrating findings into actionable recommendations.

• Advanced degree preferred (PhD, MD, PharmD, or MBA), with a strong understanding of drug development, R&D strategy, and value creation in biopharma.

• Demonstrated ability to work cross-functionally across research, clinical development, commercial, and manufacturing teams.

• Experience in portfolio modeling, scenario planning, or strategic investment frameworks.

Here’s What You’ll Bring to the Table (Preferred Qualifications)

• Advanced verbal and written communication skills to deliver a compelling narrative/message to senior stakeholders in the organization

• Experience in biopharma investment analysis, forecasting, or corporate strategy at a global level.

• Ability to translate scientific and financial trade-offs into executive-level decision-making insights.

• Familiarity with clinical trial design and regulatory pathways to understand pipeline development and market entry challenges.

• A desire to make an impact as part of a high-growth, transformational company that is Bold, Relentless, Curious, and Collaborative.

At Moderna, we believe that when you feel your best, you can do your best work.  That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between.

• Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs
• A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
• Lifestyle Spending Accounts to personalize your well-being journey
• Family planning and adoption benefits
• Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
• Savings and investment opportunities
• Location-specific perks and extras

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.  

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. 

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. 

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. 

Our Working Model 

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. 

Moderna is a smoke-free, alcohol-free, and drug-free work environment. 

Equal Opportunities

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.  Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. 

Accommodations

We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. 

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at [email protected]. 

Export Control Notice

This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant’s ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role Moderna is unable to sponsor non-U.S. persons to apply for an export control license.

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