Associate Director, Pharmacometrics

Employment Type: Full-time

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:
The Associate Director, Pharmacometrics will collaborate with cross-functional stakeholders across Structure Therapeutics to support discovery, preclinical development, and clinical development programs. This role will contribute to translational strategies that inform clinical development and help define optimal dose, route, and regimen. The Associate Director will lead or support pharmacometrics deliverables for regulatory submissions and health authority interactions and communicate key results and recommendations to internal teams and, as appropriate, external partners. This position reports to the Executive Director, Head of Pharmacometrics.

Job Responsibilities:

• Support model-informed drug development across discovery and development programs.
• Represent Pharmacometrics on cross-functional teams, providing quantitative input to strategy, dose selection, and trial design.
• Plan, execute, and document pharmacometrics analyses, including PopPK, PK/PD, and exposure-response modeling, simulation, and reporting.
• Develop and maintain Shiny-based applications to support data visualization and model-informed workflows, with potential incorporation of AI/ML-enabled features where appropriate.
• Coordinate external vendors and consultants and review deliverables for scientific quality and timeliness.
• Contribute to pharmacometrics content for regulatory submissions and health authority responses.
• Support functional process improvements, including templates, workflows, and modeling infrastructure, as well as other departmental needs such as due diligence.

Core Competencies, Knowledge, and Skill Requirements:

• Strong cross-functional collaboration and communication skills, with the ability to clearly present quantitative findings to diverse audiences.
• Strong programming and analytical skills to support high-quality PK/PD and pharmacometrics analyses.
• Working knowledge of regulatory expectations for pharmacometrics and clinical pharmacology deliverables.
• Strong project management skills, including prioritization, execution, and timeline management in a fast-paced environment.
• Ability to manage external partners effectively with appropriate independence and judgment.

Qualifications:

Education: 

• Advanced degree (PhD, PharmD, MS) in Engineering, Mathematics, Statistics, Pharmaceutical Sciences, or a related field.

Experience:

• 5+ years of relevant drug development experience in biotech, pharma, or a related consulting environment.
• Hands-on experience with commonly used pharmacometric approaches, including PopPK, PK/PD, exposure-response, and related statistical or quantitative modeling methods.
• Proficiency with pharmacometrics and data analysis tools such as NONMEM, R, and one or more of Monolix, Phoenix WinNonlin, MATLAB, or SAS, as appropriate.
• Experience supporting pharmacometrics or clinical pharmacology deliverables for regulatory submissions and/or health authority interactions.
• Experience with dataset creation, data assembly, review, and visualization in support of modeling analyses.
• Experience applying AI/ML in drug development is preferred.
• Experience in small-molecule development is preferred; cardiometabolic experience, including type 2 diabetes or obesity, is preferred; PBPK experience using Simcyp and/or GastroPlus is preferred.

Travel Required:

• Approximately 10–15%, including scientific conferences and periodic travel to company sites as needed (potential travel to China and periodic time in the SSF, CA office).

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $193,000-$225,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.

Notice to Recruiters/Staffing Agencies

Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.

We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.

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