Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
Job Title: Director, Payer Marketing
Location: Waltham, MA \ Conshohocken, PA
About the Role
The Director, Payer Marketing will lead the development of strategic, evidence-based payer value communication tools that support access and reimbursement for Madrigal Pharmaceuticals’ therapies in Metabolic Dysfunction-associated Steatohepatitis (MASH). This role translates complex clinical, economic, and real-world evidence into compelling value propositions for U.S. payers—across Commercial, Medicare, and Medicaid channels—while ensuring alignment with brand positioning and field execution strategies.
A key responsibility of this role is to develop and adapt value communication resources to meet the specific needs of the Key Account Director (KAD) and Regional Account Director (RAD) teams. This includes crafting tailored materials—such as payer value decks, cost-impact claims, and summary tools—that reflect the differentiated value of Rezdiffra in IDNs, GI super groups, and regional managed care organizations. By aligning content with local market dynamics, formulary criteria, and institutional drivers, the Director will enable both KADs and RADs to effectively communicate value and support account-level pull-through.
The Director will work cross-functionally with Market Access, Brand Marketing, HEOR, and Field Access teams to ensure value messages are consistent, credible, and responsive to evolving payer scrutiny, policy shifts, and competitive pressures. This role is critical to maintaining Rezdiffra’s leadership position by enabling internal stakeholders to deliver tailored, high-impact access communications across customer archetypes.
Key Responsibilities
Value Communication Strategy & Execution
• Develop and execute comprehensive value communication strategies to drive payer coverage, reimbursement, and pull-through across Commercial, Medicare, and Medicaid markets.
• Lead the development of payer value stories and other messaging resources supported by clinical evidence and health economics data to demonstrate the differentiated value of Madrigal’s therapies.
• Integrate brand strategy into payer messaging by partnering closely with Brand Marketing to ensure alignment across patient, HCP, and payer communication channels.
• Tailor value narratives to specific payer archetypes and coverage scenarios, anticipating access barriers and articulating clear justifications for formulary inclusion.
• Continuously refine the overall value proposition based on evolving payer needs, policy shifts, and competitor developments.
• Collaborate with HEOR and Medical to ensure alignment of payer messaging with evidence generation and scientific narratives.
• Translate clinical trial data, real-world evidence, and economic analyses into actionable insights for payer audiences.
• Oversee the development of cost-effectiveness analyses, budget impact models, and population health value tools in partnership with HEOR.
• Work with the commercial team to embed access and affordability messaging into HCP engagement plans and marketing tactics.
• Design omnichannel content strategies that reinforce the product value proposition via digital, email, portal, journal, and conference-based touchpoints.
Payer Tools & Field Enablement
• Create payer engagement materials for National Access Directors (NADs), Regional Access Directors (RADs), and Key Account Directors (KADs), including objection handlers, FAQs, and scenario-based field tools.
• Develop and lead training initiatives to ensure NADs, RADs, and KADs are confident in communicating the clinical and economic value of Madrigal’s therapies.
• Continuously iterate on tools based on field feedback, competitive insights, and evolving payer evidence requirements.
Monitoring Market Evolution
• Anticipate and interpret trends in U.S. payer evidence requirements.
• Support the development of strategies that adapt Madrigal’s value communication in response to new competitive entrants and payer management approaches.
• Serve as a strategic thought partner in identifying emerging threats and opportunities in value demonstration.
Strategic Initiative Support
• Participate in cross-functional initiatives such as value-based contract concept development, contract strategy refinement, and payer segmentation analyses.
• Collaborate with Market Access, Pricing, and Trade teams to ensure consistency and synergy across all access-related strategies.
• Contribute insights and evidence inputs to strategic planning and pricing committee discussions as needed.
Compliance / Governance
• Ensure all payer-facing materials are accurate, fair-balanced, and compliant with legal, regulatory, and industry standards.
• Collaborate with Legal, Regulatory, and Compliance teams to review and approve value communication content.
About You
Key Competencies & Leadership Attributes
• Proven ability to synthesize clinical, economic, and market data into compelling payer narratives.
• Strong understanding of U.S. payer dynamics, field access operations, and the interplay between brand and market access strategy.
• Experience collaborating with commercial and field teams to drive access pull-through and payer engagement.
• Proven ability to lead cross-functional teams and manage external partners/vendors.
• Strong communication skills, with experience crafting messages for both internal field teams and external payer audiences.
• Detail-oriented with strong project management skills and the ability to execute against tight timelines.
• Strategic mindset with a proactive approach to addressing market access challenges and opportunities.
Education & Experience
• Advanced degree preferred (PharmD, MPH, MHA, PhD, or MBA).
• Minimum 12+ years of experience in the pharmaceutical/biotech industry, with at least 5 years in payer value communications or market access.
• Track record of developing impactful payer materials in support of field execution.
• Therapeutic experience in metabolic, hepatic, or cardiovascular disease strongly preferred.
• Experience in adjacent functions such as Market Access Strategy, Deal Evaluation, Payer Account Management, etc. highly preferred.
Travel Requirement: Approximately 20% travel for cross-functional collaboration, training, and field engagement.
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $210,000 - $256,000 per year.
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].
Top Skills
What We Do
Madrigal Pharmaceuticals, Inc. (Nasdaq: MDGL) is a clinical-stage biopharmaceutical company pursuing novel therapeutics for non-alcoholic steatohepatitis (NASH), a liver disease with high unmet medical need. Madrigal’s lead candidate, resmetirom, is a once daily, oral, thyroid hormone receptor (THR)-β selective agonist that is designed to target key underlying causes of NASH in the liver. Resmetirom is currently being evaluated in two Phase 3 clinical studies, MAESTRO-NASH and MAESTRO-NAFLD-1, designed to demonstrate multiple benefits in patients with NASH. For more information, visit www.madrigalpharma.com
