Director, Enterprise Applications

Position Summary

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

This role owns the business systems that support Nurix's path from clinical trials through commercialization. You will be the primary IT partner to Clinical Operations, Regulatory, Quality, and Commercial leadership, ensuring the technology they depend on works and evolves with the business. 

The scope includes clinical systems (EDC, eTMF, pharmacovigilance, regulatory submissions), quality and training platforms, and commercial systems as they come online. You manage vendor relationships for delivery outcomes, work with Quality on validation requirements, and coordinate with IT Strategy & Vendor Operations on contracts and shared infrastructure. 

This is a strategic role with hands-on expectations. You will define requirements, design workflows, run implementations, and ensure adoption. If a vendor falls short or a gap emerges, you can configure, troubleshoot, or build what's needed. You're not above the work. 

The goal is to function as a mini-CIO for the life sciences enterprise application portfolio. Over time, the role grows with the company. As Nurix advances toward commercial stage, you will shape the systems strategy and build a team to support it. 

Primary Responsibilities 

Business partnership 

• Serve as primary IT partner to Clinical Operations, Regulatory, Quality, and Commercial 

• Translate business needs into system requirements and implementation plans 

• Own stakeholder satisfaction for the enterprise applications portfolio 

• Proactively identify technology opportunities that enable business outcomes 

Application portfolio management 

• Own the clinical, quality, regulatory, and commercial application portfolio 

• Current systems: Medidata Rave (EDC), Wingspan eTMF, Argus (pharmacovigilance), Veeva Vault RIM (submissions), Veeva CRM, Veeva QMS, VeevaDocs, Veeva Training 

• ERP/back-office systems as commercial operations expand 

• Define application roadmap aligned to clinical milestones and commercial readiness 

• Manage system integrations, data flows, and reporting needs 

Implementation and delivery 

• Lead implementations end-to-end: requirements, configuration, testing, training, go-live 

• Coordinate with clinical PM contractor on project execution 

• Align with IT Project Manager on resource conflicts, shared vendors, and portfolio reporting 

• Manage UAT coordination, training development, and change management 

Vendor management 

• Own functional relationships with application vendors (what gets built, does it work, is it adopted) 

• Partner with Director, IT Strategy & Vendor Operations on contracts, SOWs, and vendor governance 

• Hold vendors accountable for delivery outcomes and service quality 

• Ensure vendors build internal capability, not dependency 

Compliance and quality 

• Partner with Quality on GxP validation requirements for regulated systems 

• Understand CSV principles; work alongside Qualitas and internal validation resources 

• Support FDA inspection readiness for IT-related controls 

• Ensure 21 CFR Part 11 compliance for electronic records and signatures Organization 

Required Qualifications 

• 10+ years in IT, with 5+ years in life sciences or pharmaceutical environments 

• Direct experience with clinical systems: EDC, eTMF, CTMS, safety/PV, or regulatory submissions 

• Veeva platform experience (Vault, CRM, QMS) 

• Medidata Rave experience 

• Track record leading application implementations from requirements through adoption 

• Experience managing vendors for delivery outcomes (not just contract administration) 

• Working knowledge of GxP validation principles and 21 CFR Part 11 

• Strong business analyst skills: requirements gathering, process design, stakeholder facilitation 

• Comfortable with hands-on configuration and troubleshooting when needed 

• Effective communicator with scientific, clinical, and business audiences 

• Bachelor's degree in a technical field, or equivalent experience 

Strongly Preferred Qualifications: 

• Experience supporting regulatory submissions or FDA inspection readiness 

• Commercial systems experience (CRM, market access, patient services) 

• ERP implementation or administration experience 

Organization 

Reports to:  SVP IT 

Key partners: 

• Director, IT Operations (contracts, vendor governance, shared infrastructure) 

• IT Project Manager (portfolio coordination, resource alignment) 

• Clinical PM contractor (implementation project execution) 

• Sr. Director and CISO (security, compliance) 

• USDM (system validation, GxP compliance) 

Primary stakeholders: 

• Clinical Operations leadership 

• Regulatory Affairs leadership 

• Quality leadership 

• Commercial leadership 

Salary Range: $216,000 to $251,000 Plus Bonus and Equity

Location: Brisbane, CA - Onsite 

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