Our Culture: Why work with us?
At Foghorn Therapeutics, we believe in “People First, Mission Always.”
We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.
We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.
Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.
Our Science:
The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.
Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.
The Role:
This position offers an exciting opportunity to be a key part of a research and development organization that is pioneering a new class of medicines. The Director, DMPK project representative, will provide direct support to multiple project teams across the discovery and early clinical development portfolio.
What you will be doing:
- Design and execute issue-driven ADME/PK studies to address critical discovery project needs, supporting program progression through lead optimization to early development
- Analyze and interpret preclinical ADME/PK data, communicating results and recommendations to project teams effectively
- Build and maintain strong collaborations with internal and external partners across chemistry, biology, pharmacology, CMC and other R&D disciplines
- Partner with discovery and clinical groups to design preclinical studies that inform clinical dosing strategy
- Contribute to key decisions including candidate selection, development strategy, and clinical trial design
- Author and review preclinical study reports, including nonclinical toxicology, DMPK and biomarker sections of regulatory documents
- Design and interpret PK/PD, efficacy and toxicology studies in collaboration with cross-functional teams
- Stay current with DMPK scientific literature and emerging technologies to identify potential applications for ongoing programs
- Help finalize clinical study protocols and reports with focus on DMPK aspects
Requirements
About You:
- PhD or equivalent in relevant field
- 7+ years of experience in pharmaceutical/biotechnology setting
- Strong understanding of DMPK principles and ADME/PK assays in drug development
- Demonstrated expertise in human PK and dose projections
- Proven track record as DMPK project representative/leader on multiple project teams
- Up-to-date knowledge of regulatory guidance related to ADME/PK characterization, drug-drug interaction, and human ADME studies
- Experience with IND preparation and other regulatory documents
- Strong communication and collaboration skills with ability to effectively convey ADME/PK risks
- Experience with covalent modalities, PROTACs and parenteral delivery preferred
- Demonstrated ability to work effectively in cross-functional team environments
Benefits
- Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- BCBS PPO and PPO HSA plans
- BCBS Dental Plan
- EyeMed Vision Plan
- FSA and HSA for medical expenses and dependent care expenses
- 401(k) Program via Fidelity with the company match
- Corporate Wellness Program
- Unlimited Paid Time Off policy
- Winter shut down
- 12 weeks of 100% paid parental leave for birthing/primary parent and primary guardian in case of adoption and 3 weeks of 100% paid parental leave for non-birthing/non-primary parent/guardian.
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking, subsidized commuter passes, or a $100 monthly stipend for walking/biking to work
- Company lunches on Wednesdays
- Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
- Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
- Base salary range for this position: $200,000–$240,000 per year
Top Skills
What We Do
Foghorn Therapeutics is pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, an untapped opportunity for therapeutic intervention. Our proprietary Gene Traffic Control® platform gives us an integrated, mechanistic understanding of how the various components of the chromatin regulatory system interact, allowing us to identify, validate and potentially drug targets within the system.
