Director of Data Science and Bioinformatics

Posted 6 Days Ago
Be an Early Applicant
San Carlos, CA, USA
In-Office
196K-244K Annually
Expert/Leader
Biotech
The Role
Lead and grow the Data Science and Bioinformatics function for genomics clinical products. Build bioinformatics capability, architect scalable AWS infrastructure, implement MLOps and validation frameworks, establish quality and reproducibility standards for NGS algorithms, and hire/mentor a high-performing team while partnering cross-functionally to productize pipelines.
Summary Generated by Built In

This is an exciting opportunity to lead and grow the Data Science and Bioinformatics function supporting Natera's Women's Health and Organ Health product portfolios. In this role, you will build the bioinformatics capability within the Data Science development team, establish scalable AWS cloud infrastructure, and ensure the quality and reproducibility of the genomic algorithms powering our clinical products.

PRIMARY RESPONSIBILITIES:

Strategy and Vision

  • Build and define the Bioinformatics function within the Data Science development team, identify technical tooling gaps, and execute a roadmap to advance genomics-based algorithm development.
  • Establish and enforce pipeline and algorithm quality standards, including review processes, validation frameworks, and documentation practices

Infrastructure and Automation

  • Own and architect scalable AWS-based data science and bioinformatics infrastructure, ensuring quality, reproducibility, and reliable deployment of Next-Generation Sequencing (NGS) algorithms.
  • Implement MLOps tooling and automated validation frameworks to support reliable algorithm deployment into clinical production.

Cross-Functional Collaboration

  • Partner with Research, Product Development, Laboratory Operations, Engineering, and Quality teams to implement stable, scalable pipelines and support successful productization

Team Leadership

  • Lead, mentor and hire a high-performing team of bioinformaticians and data scientists, establishing technical quality standards and clear operational ownership.
  • Build technical depth within the team to support expanding product roadmaps across Women's Health and Organ Health.

QUALIFICATIONS:

  • Master of Science or Ph.D. in a quantitative technical discipline (Biostatistics, Bioinformatics, Computer Science, Physics, Applied Mathematics, or equivalent).
  • Minimum of 10 years of experience in Data Science or Bioinformatics, with at least 5 years of direct people management experience leading technical teams.
  • Hands-on experience architecting AWS cloud infrastructure for data-intensive bioinformatics workloads and NGS pipeline execution.
  • Demonstrated ability to identify capability gaps independently, build scalable infrastructure, and drive execution without waiting for formal structure.
  • Strong communicator who builds cross-functional alignment across Research, Engineering, and Quality teams through technical clarity, direct engagement, and data-driven reasoning.
  • Track record of developing bioinformatics talent and delivering computational pipelines that support commercial product development.

PREFERRED QUALIFICATIONS:

  • Experience developing software and pipelines within regulated environments (CLIA, FDA, or ISO framework).
  • Experience with MLOps frameworks and pipeline tools (MLflow, Nextflow, WDL, Docker).
  • Advanced knowledge of statistical inference, machine learning, and genomic data processing.

Compensation & Total Rewards 

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of  hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

  • Annual performance incentive bonus

  • Long-term equity awards

  • Comprehensive health benefits (medical, dental, vision)

  • 401(k) with company match

  • Generous paid time off and company holidays

  • Additional wellness and work-life benefits

Compensation Range
$195,600$244,450 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:
- BBB announcement on job scams 
- FBI Cyber Crime resource page 

Skills Required

  • Master of Science or Ph.D. in Biostatistics, Bioinformatics, Computer Science, Physics, Applied Mathematics, or equivalent
  • Minimum of 10 years of experience in Data Science or Bioinformatics
  • At least 5 years of direct people management experience leading technical teams
  • Hands-on experience architecting AWS cloud infrastructure for data-intensive bioinformatics workloads and NGS pipeline execution
  • Demonstrated ability to identify capability gaps, build scalable infrastructure, and drive execution independently
  • Strong cross-functional communication skills to align Research, Engineering, and Quality teams
  • Track record of developing bioinformatics talent and delivering computational pipelines for commercial product development
  • Experience developing software and pipelines within regulated environments (CLIA, FDA, or ISO)
  • Experience with MLOps frameworks and pipeline tools (MLflow, Nextflow, WDL, Docker)
  • Advanced knowledge of statistical inference, machine learning, and genomic data processing

Natera Compensation & Benefits Highlights

The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Natera and has not been reviewed or approved by Natera.

  • Healthcare Strength Medical plan choice, fertility support, and free Natera tests for employees and families are emphasized alongside dental, vision, and life/disability coverage. These elements indicate robust core health coverage.
  • Equity Value & Accessibility An Employee Stock Purchase Plan is available, and equity is described as a significant part of compensation in some roles. This accessibility to ownership can meaningfully augment overall pay.
  • Leave & Time Off Breadth A flexible, no‑accrual PTO policy and parental leave are positioned as part of the package. This breadth suggests meaningful time‑off provisions are included.

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The Company
HQ: Austin, TX
6,000 Employees
Year Founded: 2004

What We Do

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. Where some set out to build a test, we set out to achieve a mission: change the management of disease worldwide by using DNA testing to proactively inform treatment. Through a cfDNA technology platform approach, we've pioneered noninvasive testing in unlimited applications—each with their own potential to revolutionize care for patients. #TeamNatera includes clinicians, scientists, biostatisticians, researchers, and laboratory professionals from around the world. Our diverse teams blend a passion for patients with deep clinical, scientific, and technological roots. Natera’s tests are validated by more than 100 peer-reviewed publications that demonstrate high accuracy.

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