Consultant Call – DMPK (Peptide Therapeutics)
Constructive Bio is seeking an experienced DMPK or PK/PD (preclinical pharmacology) consultant to support ASAP the design and delivery of our peptide development programs. Our pipeline includes engineered peptides incorporating non-canonical amino acids, and we need expertise to translate molecular design into clear DMPK strategies and data packages. We need someone experienced available now.
Scope of work:
- Plan and review in vivo studies (PK, bioavailability, half-life, clearance routes, immunogenicity considerations).
- Plan and review in vitro assays (plasma stability, protease resistance, plasma protein binding, permeability).
- Advise on overall DMPK strategy for peptides, including study design, interpretation, and regulatory expectations.
- Analyse data, highlight risks, and recommend next steps to guide project teams.
- Benchmark against industry best practices and prepare input suitable for preclinical packages.
- Support vendor/CRO selection and study oversight.
Requirements:
- Track record in DMPK for peptides or biologics, ideally in pharma/biotech. Evidence for the track record needs to be provided.
- Experience with PK/PD modelling, half-life extension technologies, and translation from animal to human.
- Ability to work flexibly as a consultant, providing both strategic guidance and hands-on analysis.
- Strong communication skills to work with internal scientists and external partners.
Desirable:
- Experience of in vitro and in vivo safety and toxicology studies
- Knowledge and preparation of IND documents would be an advantage
We are open to short- or medium-term consulting arrangements.
Please note that we work in a dog-friendly office
Top Skills
What We Do
With the power to skillfully write meaningful DNA sequences, we embark on a new era where precise control over biology and the manipulation of matter in our environment is possible. Constructive Biology is a spin out from the laboratory of Prof. Jason Chin at the MRC Laboratory of Molecular Biology in Cambridge. Our platform allow us to fundamentally reprogram the genetic code, and make molecules that nature could not make before. We will use our technologies to biosynthesize new classes of enzymes, pharmaceuticals and biomaterials. If you would like to join our team, get in touch
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