Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).
Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.
The Opportunity
We are seeking a Contract Compensation Manager to support Amylyx through a period of growth. In this role, you will work closely with Talent Acquisition and the Total Rewards team to benchmark roles, evaluate job descriptions, and ensure competitive, equitable, and consistent offers. This is a unique opportunity to apply deep compensation expertise in a fast-paced environment where high-quality decision-making directly impacts our ability to attract top talent and support the communities we serve.
This role is ideal for someone who thrives in a fast‑paced environment, enjoys analytical problem‑solving, and partners seamlessly with Talent Acquisition to ensure consistent, high‑quality offer outcomes.
Responsibilities
Core Focus Areas
- Partner closely with hiring managers and Talent Acquisition to benchmark new and evolving roles, validate leveling, and ensure job descriptions align with internal frameworks and external market data
- Provide compensation insights to TA and hiring managers, helping shape hiring strategies for new or hard‑to‑fill roles
- Advise TA on offer negotiation strategies to ensure consistency, fairness, and timely closings
- Partner with HR colleagues to align new roles to our leveling framework and ensure consistency across functions
- Support offer development, ensuring all offers reflect our compensation philosophy, internal equity, and compliance with pay standards
- Conduct market pricing using Radford and other survey data; prepare clear, well‑supported recommendations
- Maintain internal equity across teams and functions, analyzing trends, compression risks, and leveling consistency
Operational & Analytical Support
- Build and maintain Excel-based analytical tools to support fast, accurate offer modeling.
- Perform ad-hoc compensation analyses to support business decisions, including pay ranges, job mapping, and compensation health metrics
- Maintain a library of market data, benchmarks, and survey inputs to support hiring needs.
- Enhance existing tools, templates, and job benchmarking resources to enable TA to work more efficiently
- Develop quick‑reference guides or job-matching tools to speed up pricing and leveling
Cross‑Functional Collaboration
- Serve as a subject matter expert on compensation practices for TA, HRBPs, and business leaders.
- Advise on compensation process improvements, including opportunities to streamline offer workflows, enhance data quality, and improve stakeholder experience.
- Contribute to broader Total Rewards and HR projects as needed
Required Qualifications
- 6+ years of compensation experience in biotech, pharma, high-growth tech or similar dynamic environments
- Preference for candidates with experience in pre‑commercial biotech, ideally with exposure to scaling compensation practices in advance of commercial launch
- Prior experience with Radford/AON and other relevant market surveys
- Exceptional analytical skills and expert‑level Excel proficiency.
- Strong attention to detail, with a commitment to producing accurate and thorough, market‑aligned analyses
- Ability to manage sensitive information with the highest level of confidentiality
- Highly resourceful, organized, and comfortable working in a fast‑paced, ambiguous environment
- Strong communication skills with the ability to translate complex data into clear guidance for non‑comp stakeholders
- Experience with equity analysis and benefits is a plus
Work Location and Condition
- At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis. Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
- When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.
Compensation
The hourly pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.
To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn.
To return to our website please click here.
Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Skills Required
- 6+ years of compensation experience in biotech, pharma, high-growth tech or similar environments
- Experience with Radford/AON and other market surveys
- Expert-level Excel proficiency and strong analytical skills
- Strong attention to detail and ability to produce accurate, market-aligned analyses
- Ability to manage sensitive information with highest confidentiality
- Highly resourceful, organized, and comfortable in a fast-paced, ambiguous environment
- Strong communication skills; translate complex data into clear guidance for non-compensation stakeholders
- Ability to attend meetings at Cambridge, MA on a regular basis (preference for New England residents)
- Experience with equity analysis and benefits
- Preference for candidates with pre-commercial biotech experience and scaling compensation practices
What We Do
Amylyx Pharmaceuticals, Inc. is a global company committed to the mission of discovery and development of treatments for relentless and progressing neurodegenerative diseases. We work collaboratively across everything we do, aspiring to help support and create #MoreMoments for the neurodegenerative disease community. Community Guidelines: https://bit.ly/3C1v1wz Please be aware of potential phishing scams imitating Amylyx. All authentic communications from Amylyx will be from the Amylyx.com domain.
