Job Summary
As a Senior Clinical Genomic Scientist, you will assume a leadership role in variant curation, data analysis, and interpretation in alignment with ACMG guidelines. This position significantly contributes to interpreting genomic data within clinical contexts, providing expertise, and guiding junior team members.
Qualifications and Experience:
Education:
Senior Clinical Genomic Scientist:
Degree: PhD or MD in clinical medicine, genetics, molecular biology, or equivalent.
Relevant Experience: 7+ years of demonstrated experience in the field.
Certification: Optional: MB(ASCP).
Profound knowledge of genomic variation, its impact on human diseases, and expert-level literature curation methodologies.
Mastery in variant detection, molecular disease mechanisms, functional assays, and computational analysis.
Technical expertise in clinical medicine, genetics, genomics, or molecular biology, coupled with extensive experience in data quality assessment.
Exceptional verbal and written communication skills, capable of conveying complex genetic information effectively.
Proficient in the application of ontologies for medical annotation and experienced in bioinformatics analysis for variant identification within genomic datasets.
Duties and Responsibilities:
50%: Lead and oversee the curation of variants, genes, and gene-disease correlations following ACMG guidelines, utilizing extensive datasets, online resources, and published literature.
30%: Perform comprehensive analysis of clinical genomics data involving various techniques such as next-generation sequencing, Sanger sequencing, metabolomics, and chromosomal microarray.
10%: Draft clinical reports, manage validation processes, refine methodologies, and present findings in meetings, demonstrating leadership and expertise.
10%: Provide mentorship, guidance, and training to junior team members, actively participating in process improvements and additional duties as needed.
PHYSICAL DEMANDS AND WORK ENVIRONMENT:
Frequently required to sit.
Frequently required to utilize hand and finger dexterity.
Frequently required to talk or hear.
EEO Statement:
Baylor Genetics is proud to be an equal opportunity employer dedicated to building an inclusive and diverse workforce. We do not discriminate based on race, religion, color, national origin, sex, sexual orientation, age, gender identity, veteran status, disability, genetic information, pregnancy, childbirth, or related medical conditions, or any other status protected under applicable federal, state, or local law.
This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.
Skills Required
- PhD or MD in clinical medicine, genetics, molecular biology, or equivalent.
- 7+ years demonstrated experience in clinical genomics.
- Profound knowledge of genomic variation and expert-level literature curation methodologies.
- Mastery in variant detection, molecular disease mechanisms, functional assays, and computational analysis.
- Technical expertise in clinical medicine, genetics, genomics, or molecular biology and experience in data quality assessment.
- Exceptional verbal and written communication skills.
- Proficiency in application of ontologies for medical annotation and bioinformatics analysis for variant identification (e.g., HPO).
- Knowledge and application of ACMG guidelines for variant classification and interpretation.
- Mentorship, training, and leadership experience guiding junior team members.
- MB(ASCP) certification.
- Experience with WGS, WES, NGS, Sanger sequencing, chromosomal microarray, and metabolomics case review.
- Familiarity with genomic analysis platforms and confirmatory testing review and recommendations.
- Experience with Microsoft Excel, Word, PowerPoint, and Outlook.
- Experience in workflow improvement, project leadership, and quality assurance in a clinical laboratory setting.
What We Do
Baylor Genetics is a joint venture of H.U. Group Holdings, Inc. and Baylor College of Medicine, including the #1 NIH-funded Department of Molecular and Human Genetics. Located in Houston’s Texas Medical Center, Baylor Genetics serves clients in 50 states and 16 countries.
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