Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).
Benefits We Offer:
- 100% Medical, Dental & Vision Coverage for Employees
- Paid Time Off and Paid Holidays
- 401K match up to 5%
- Educational Benefits for Career Growth
- Employee Referral Bonus
- Flexible Spending Accounts:
- Healthcare (FSA)
- Parking Reimbursement Account (PRK)
- Dependent Care Assistant Program (DCAP)
- Transportation Reimbursement Account (TRN)
Axle is seeking a highly ambitious, adaptable, structured, and detail-oriented Bioinformatics Scientist to join our vibrant team at the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research (DIR), Research Technologies Branch (RTB), Integrated Data Sciences Section (IDSS) in Bethesda, MD.
Responsibilities:
Address bioinformatics, scientific computing, and data analysis needs of users within the Division of Intramural Research (DIR) at NIAID and their collaborators by lending expertise in the proper statistical design of biological experiments involving high-throughput genome-scale technologies, data mining and knowledge discovery techniques, automated workflow development, statistical and scientific experimental design consulting.
Provide bioinformatics support to include somatic and germline variant calling and analysis, single-cell and bulk gene expression analysis, de novo assembly of genomes and transcriptomes, comparative genomics of model and non-model organisms, proteomics, ChIP-seq, ATAC-seq, and the development of high-throughput pipelines for the analysis of the above data modalities.
Provide programming and troubleshooting support to the Research Technologies Branch (RTB) of the National Institute of Allergy and Infectious Diseases (NIAID) and collaborating Institutes in the dissemination of research data.
Perform computational data analysis on genomic and clinical research data.
Work with staff on scientific programming and experimental design. Provide statistical support/analysis on research data.
Contribute to and co-author scientific publications in leading peer-reviewed journals.
Contribute to the development of a scalable and flexible resource to provide NGS bioinformatics, structural biological and computational, machine learning data support to NIAID scientists and investigators.
It is expected that the bioinformatics scientist will need strong skills in the following:
NGS analysis (whole-exome, whole-genome, RNA-seq, ChIP-Seq, both long- and short-read technologies, etc.)
Statistical modeling
Scripting
Biological interpretation
Specific Qualifications:
Ability to obtain and maintain a Public Trust Security clearance
Minimum Bachelor’s degree in related field, Master’s or Ph.D. preferred
4+ years of experience in bioinformatics
2+ years of experience developing and maintaining production bioinformatics pipelines
Expert in two (2) of the following languages: Python, R, C/C++, sh/bash
Experience building images using one (1) of the following: Docker, Podman, Singularity/Apptainer
Expert in one (1) pipeline framework: Snakemake, Nextflow, CWL/WDL
Expertise building technical and user documentation for tools, pipelines, and applications
Experience building pipelines locally on-premise using available HPC infrastructure
Experience building pipelines/applications in the Cloud with AWS/GCP/Azure is a plus
Experience building applications using one (1) of the following frameworks is a plus: Django, Flask, RShiny, Electron, Flutter, React
Experience working in a laboratory setting is a plus but not required
Please submit a cover letter with your resume that addresses the following questions:
- What experience do you have working with large datasets and compute clusters?
- Describe your experience building workflows/pipelines and/or using bioinformatics software and tools to analyze data.
- What programming languages are you comfortable using for bioinformatics data analysis?
- What bioinformatics areas are you familiar with? (e.g., single cell, bulk genomics, transcriptomics, epigenetics, flow, spatial, metagenomics, etc.)
- What life science disciplines do you have experience in? (e.g., immunology, infectious disease, cancer research, etc.)
- Provide examples of basic machine learning/AI concepts and/or how you've applied them in bioinformatics data analysis.
Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individuals assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.
The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment based on age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.
Accessibility: If you need an accommodation as part of the employment process please contact: [email protected]
This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.
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Skills Required
- Ability to obtain and maintain a Public Trust Security clearance
- Minimum Bachelor's degree in a related field
- 4+ years of experience in bioinformatics
- 2+ years of experience developing and maintaining production bioinformatics pipelines
- Expertise in two of Python, R, C/C++, or sh/bash
- Experience building images using Docker, Podman, or Singularity/Apptainer
- Expertise in one pipeline framework: Snakemake, Nextflow, CWL, or WDL
- Expertise building technical and user documentation for tools, pipelines, and applications
- Experience building pipelines locally on-premise using HPC infrastructure
- Master's or Ph.D. degree
- Experience building pipelines or applications in AWS, GCP, or Azure
- Experience building applications with Django, Flask, RShiny, Electron, Flutter, or React
- Experience working in a laboratory setting
What We Do
Axle Informatics is a bioscience and information technology company that offers advancements in translational research, health informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we develop and apply research tools and techniques that empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH) by offering the responsiveness of a small business coupled with the experience, breadth, and depth of a large organization.
