Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking an Associate Scientist to join the discovery DMPK group in Chemistry Department. The successful candidate will primarily focus on analysis of biological samples using state of the art LC-MS (High resolution mass spectrometry is a plus) and qPCR assays, in support of discovery programs.
Responsibilities
- Perform LC-HRMS or stem-loop qPCR based quantitative bioanalysis in a variety of biological matrices (fluids and tissues) in support of pharmacokinetics and tissue clearance studies.
- Understand and follow sample preparation protocols applicable to assigned tasks.
- Document experimental procedure and results accurately and meticulously.
- Execute all assays in a timely manner to meet deadlines.
Requirements
- Bachelor of Science in Chemistry, Biology. Biochemistry, or related field
- 3+ years of lab experience
- Hands-on experience of LC-MS or multiple detection techniques.
- Hands-on experience of sample handling from biological matrices
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment
Preferred
- Demonstrated practical understanding of liquid chromatography and mass spectrometry
- Experience with high-throughput sample analysis applying bioanalysis assays.
- Experience working on oligonucleotides
- Self-motivated team player with the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Skills Required
- Bachelor of Science in Chemistry, Biology, Biochemistry, or related field
- 3+ years of laboratory experience
- Hands-on experience with LC-MS or multiple detection techniques
- Hands-on experience handling samples from biological matrices
- Demonstrated innovation, creativity, and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player able to thrive in a fast-paced, matrixed environment
- Practical understanding of liquid chromatography and mass spectrometry
- Experience with high-throughput sample analysis applying bioanalysis assays
- Experience working on oligonucleotides
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
