Company Overview:
Strand Therapeutics is a clinical stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies to patients.
Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological engineers working together at MIT who were seeking to apply the concept of the emerging field of mRNA therapeutics. Strand's technology is therapeutic-area and mRNA modality agnostic where therapeutic proteins are encoded onto modified, self-replicating, or circular mRNA backbones which in turn are programmed with cell-specific sensors and circuits.
Today, Strand has established three platforms with one clinical stage asset and several programs in preclinical development as well as early discovery. Our lead program, STX-001, is currently being evaluated in a phase 1 clinical trial for solid tumors. Our corporate headquarters is located in the Fenway district of Boston, Massachusetts.
Become the next standout single strand!
Job Summary:
Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.
We are looking for a highly motivated and innovative candidate for the role of Associate Scientist I of mRNA Process Development. The expectation is that the Associate Scientist I will have experience independently executing mRNA process development experiments and production efforts. Reporting to Principal Associate Scientist of mRNA Process Development, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for Strand along with a desire to conquer new challenges.
Primary Responsibilities:
- Responsible for execution of mRNA production and purification development activities appropriate for GMP manufacturing.
- Responsible for running and developing analytical methods and assays.
- Support screening, optimization, and scale-up efforts for enzymatic reactions, chromatographic separations and filtration processes including, ultrafiltration, diafiltration, and sterile filtration.
- Assist with production of materials for formulation and discovery experiments
- Execute studies for process improvements and advancements.
Qualifications:
- BS with 1-2+ years of directly related experience. Degree emphasis in Biochemistry, Chemical Engineering, Molecular Biology, Bioengineering, Molecular Medicine, Genetics or related field preferred.
- This position requires conducting laboratory experiments, excellent documentation review and writing skills, and the flexibility to work on multiple projects as needed.
- Basic knowledge of purification of biologics such as chromatography and filtration.
- Understanding of nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for macromolecules.
- Knowledge of ÄKTA systems and UNICORN control software preferred.
- Experience with TFF and UFDF principles preferred.
- Availability to be able to work flexible hours/shifts required.
- Track record of completing deliverables within specified timelines.
- Independently motivated, thinks outside the box, and good problem-solving ability.
- Excellent organizational skills and attention to detail.
- Able to multi-task in an extremely fast-paced environment with changing priorities.
Strand offers a fast-paced, entrepreneurial, team-focused small company environment. We also offer a top-notch benefits package (health, dental, life, open PTO, onsite lunch catering, commuter support and more) and work/life flexibility and integration. Being part of the Strand team allows you to become part of a small team that supports professional development while working together to meet Strand’s goals.
Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.
Job Type: Full-time
Salary: $74,000 - $79,000 annually plus bonus and equity incentives
Top Skills
What We Do
Strand was started by biological engineers working together at MIT. Building on the idea of creating smart therapies that are capable of making sophisticated decisions, they sought to apply the concept of the emerging field of mRNA therapeutics. This area was untapped by traditional synthetic biology, which led them to build their own mRNA “programming language,” creating the world’s first platform for mRNA smart therapies.
Strand’s mRNA programming technology promises to make mRNA therapies safer and more effective by programming the location, timing, and intensity of therapeutic protein expression inside a patient’s body using mRNA-encoded logic circuits. These circuits can implement cell-type specific expression by sensing and classifying the unique miRNA expression signatures of cells, as well as controlling the dosage of protein expression by responding to exogenously administered small molecules.
