Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
This position is in the Analytical Development (AD) Group within the Technical Operations organization. An Associate Scientist III will support method development/validation activities for new drug substances and drug product. They will also support testing required for GLP Toxicology and cGMP Clinical Trial material release, as well as stability studies. This position reports to either AD Management, or Senior AD staff.
Responsibilities
- Know and adhere to cGMP policies and procedures and relevant SOPs
- Independently provide accurate analytical results in support of new and on-going projects
- Independently meet project timelines and deliverables
- Perform testing of samples to support batch release and stability studies
- Perform portions of analytical techniques, such as HPLC, GC, FTIR, UV/Vis, LC/MS, KF, etc.
- Assist with the design and initiation for development of analytical methods and improvement of existing ones to support all stages of drug development process
- Handle, analyze and characterize chemicals, pharmaceuticals, and related organic molecules
- Evaluate and interpret scientific data and provide the significance of such
- Independently design and execute non-routine experiments
- Analyze data/results and interpret outcome of experiments and independently propose appropriate follow-up
- Compile data tables of results, certificate of analysis, and develop stability reports
- Write analytical test methods, protocols, and standard operating procedures
- Calibrate, maintain, and troubleshoot all analytical equipment
Requirements
- Masters in Chemistry (or related field) with 2+ years’ relevant laboratory experience in pharmaceutical/regulated environment or Bachelors in Chemistry (or related field) with 5+ years in a GMP QC or analytical laboratory environment.
- Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and cGMP policies and practices.
- Ability to correctly analyze data/results and interpret outcome of experiments and to propose appropriate follow-up.
- Strong attention to detail.
- Works well with others and in a team environment
- Can be flexible with changing priorities
Preferred
- Masters Degree
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Skills Required
- Bachelor's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or related scientific discipline.
- 0-2 years of laboratory experience (industry, academic research, internships, or co-op).
- Basic understanding of analytical chemistry principles and laboratory techniques.
- Familiarity with analytical instrumentation (HPLC, GC, FTIR, UV/Vis, LC/MS, Karl Fischer) through coursework or laboratory experience.
- Strong organizational skills and attention to detail.
- Excellent written and verbal communication skills.
- Ability to work effectively independently and within a collaborative team environment.
- Comfortable managing multiple priorities in a fast-paced environment.
- Authorization to work in the country where the role is located (current, valid authorization).
- Experience working in a cGMP or regulated laboratory environment.
- Hands-on experience with chromatography or other analytical instrumentation.
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
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