Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The Associate Director, R&D Financial Planning & Analysis (FP&A) will support the Arrowhead R&D organization in preparation of budgets, forecasts, long range plans, and strategic investments for growth. This role will collaborate with key stakeholders across the company, including but not limited to Clinical Operations, Regulatory, Medical Affairs, as well as oversight of our clinical trial portfolio. This role presents an exciting opportunity to shape R&D finance strategies, influence decision-making, and support clinical portfolio execution in a dynamic and growing organization. Excellent communication, leadership, and technical skills will be essential for this role, as well as a passion to be a part of the company's growth.
This role is based in Pasadena, California or San Diego, California, with an expectation to be in office 5 days a week.
Responsibilities
- Financial Planning & Forecasting
- Lead the annual operating plan, rolling forecasts, and long-range financial planning processes for the R&D organization.
- Support strategic initiatives such as pipeline investment decisions, external collaborations, and business development evaluations.
- Act as a trusted advisor to senior leaders, translating operational plans into financial implications.
- Analyze actual results versus plan and forecast, clearly communicating key drivers and emerging trends.
- Clinical Finance & R&D Support
- Support clinical trial budgeting, forecasting, and accrual analysis, including CRO spend, investigator grants, patient costs, and pass-through expenses.
- Monitor clinical program spend versus plan, identifying risks, opportunities, and timing impacts.
- Partner with Clinical Operations, Program Management, and Accounting to ensure accurate forecasting, spend visibility, and financial close alignment.
- Support portfolio-level decision-making, including program prioritization, scenario analysis, and development trade-offs.
- Review, evaluate, and support negotiation of CRO and clinical vendor agreements, including study budgets, change orders, and contract amendments, to ensure cost efficiency, appropriate risk sharing, and alignment with development plans.
- Provide financial diligence on clinical vendor proposals, assessing pricing structures, payment terms, scope assumptions, and financial risks in partnership with Legal, Procurement, and Clinical Operations.
- Performance Management
- Enhance financial transparency and decision support through dashboards and executive-ready materials.
- Develop and track KPIs related to R&D efficiency, clinical execution, and overall financial performance.
- Recommend actions to improve cost discipline, forecast accuracy, and resource utilization.
- Process, Systems & Continuous Improvement
- Lead enhancements to FP&A processes, models, and planning tools.
- Drive best practices in forecasting, scenario planning, and financial reporting.
- Partner with Accounting and IT on ERP and FP&A system optimization.
- Team Leadership
- Lead, mentor, and develop the R&D FP&A and Clinical Finance teams, fostering a high-performing, collaborative culture.
- Establish clear expectations, accountability, and professional development paths.
Requirements
- Bachelor’s degree in Finance, Accounting, Economics, or related field
- 10+ years of progressive FP&A experience, including 5+ years in a leadership role.
- Highly proficient in Microsoft Excel, with experience building models
- Ability to gather, analyze and interpret information for completeness and accuracy; excellent attention to detail; excellent organizational skills
- Strong communication skills, ability to effectively interact with others at all levels– within and outside of finance. Ability to tailor communication to the audience to achieve desired results
- Self-starter with the demonstrated ability to work in a fast-paced atmosphere with minimal supervision
- Working knowledge of Generally Accepted Accounting Principles (US GAAP)
Preferred:
- CPA/MBA
- Experience with FP&A Planning systems (Anaplan experience a plus)
- Experience with building financial models
- Experience with Microsoft Dynamics 365 and BI tools (e.g. Tableau, Power BI)
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
