Company Description
Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (previously BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
- We are One Team. We only succeed when we work together.
Job Description
Role purpose
As our company expands, we have created an exciting new opportunity for a 1st / 2nd Line IT Support Engineer to join our UK team at Granta Park near Cambridge.
You will support the IT systems throughout the organisation. These include setup and maintenance of desktop computers, our server environment, as well as maintain our cyber security posture. You will work with a variety of teams, based in the UK and US, and look to maintain the excellent IT standards currently practiced at Bicycle.
Key responsibilities
- Help support the Corporate IT Team at Bicycle, comprising all general day to day support activities.
- Support an internal helpdesk and triage tickets, escalating as necessary.
- Assist with IT project work whether on-site or in cloud.
- Work across departments to deliver IT-driven solutions to empower scientific R&D.
- Work with enterprise security, DR and data solutions to ensure business continuity.
- Providing routine desktop support to all staff, including the Microsoft Office suite, SharePoint online, Microsoft Teams and Windows 10/11 operating systems.
- Setting up hardware and software for new staff, being responsible for on and off boarding staff.
- Supporting and troubleshooting networking equipment and issues, including wireless.
- Working closely with the IT Team Leader to meet corporate IT goals and continue developing and strengthening our cyber security posture.
- Work with existing Manager Service Provider’s in UK and US.
- Help manage current server environments.
Qualifications
Essential
- Demonstrable experience with:
- Office365
- SharePoint
- Windows
- PowerShell
- AzureAD + SSO
- Active Directory
- MDM platforms
- Enterprise-grade networking
- Firewalls (Paolo Alto)
- SSL+IPSEC VPNs
- Enterprise-grade backup systems
- Extensive Windows desktop/server support experience.
- Must be able to commute to site 3-4 days a week.
- Experience with enterprise-grade security platforms.
- Some experience of Linux/Unix systems and administration.
- An eye for detail
Desirable
- Experience of project delivery.
- Experience working under lab conditions.
- Experience with:
- AWS
- GCP
- Azure Cloud Platform
- Long term data storage
- Veeva
- Experience of working in the life sciences.
- Awareness of Cybersecurity standards and best practices.
Additional Information
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover.
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
Top Skills
What We Do
We are Bicycle Therapeutics, a clinical-stage biopharmaceutical company. We didn’t wait for the next advance against cancer. We created it.
Based on groundbreaking work conceived in the laboratory of Sir Greg Winter with the help of Professor Christian Heinis, we are pioneering the development of bicyclic peptides, or Bicycles® – a novel class of versatile, chemically synthesized medicines. Bicycles are fully synthetic short peptides constrained to form two loops which stabilize their structural geometry. This constraint is designed to confer high affinity and selectivity, and the relatively large surface area presented by the molecule allows targets to be drugged that have historically been intractable to non-biological approaches. Bicycles represent a unique therapeutic class, combining the pharmacological properties normally associated with a biologic with the manufacturing and pharmacokinetic advantages of a small molecule, yet with no signs of immunogenicity observed to date.
Bicycles can be used as Bicycle conjugates to deliver toxin payloads and to precisely target local immune activation within tumors and as Bicycle T-cell modulators, which activate cytotoxic T-cells while circumventing the limitations of antibody and biologic therapies and better enabling combination therapy. Our lead product candidate, BT1718, is a Bicycle toxin conjugate currently being investigated in a Phase I/IIa open label dose escalation and expansion clinical trial sponsored by Cancer Research UK. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MMP), also known as MMP-14, which is highly expressed in many solid tumors.
Our strategic collaborations are based on the ability of Bicycles to address a wide variety of targets. Through collaborations with AstraZeneca, Oxurion, Innovate UK and the Dementia Discovery Fund, we work with companies that have deep therapeutic expertise outside of oncology to enable us to more efficiently develop novel medicines for patients.
