Jobs at Xenon Pharmaceuticals Inc.

Lead corporate governance and legal project management activities, including Board and committee operations, SEC and securities filings, entity management, compliance calendars, transaction data rooms, IP and trademark coordination, and legal process improvement. Support the Chief Legal Officer and Legal leadership while managing confidential information, legal technology, records, workflows, and administrative operations.

Provides GCP and GLP quality assurance support for early-stage clinical programs, including quality planning, risk assessments, audits, inspection readiness, compliance consultation, training, CAPA evaluation, root cause analysis, and regulatory inspection support. Collaborates with cross-functional stakeholders to identify and escalate quality issues, maintain data integrity, and advance GLP/GCP quality strategies across pharmaceutical R&D programs.

Manages end-to-end clinical supply activities, including study-specific planning, forecasting, packaging, labeling, distribution, inventory monitoring, accountability, returns, and destruction. Coordinates with clinical, regulatory, quality, CMC, supply chain, and external vendors to ensure compliant and timely site supply. Oversees IXRS specifications and monitoring, vendor budgets, supply releases, documentation, KPI reporting, root-cause analysis, and continuous improvement across international clinical trials.

Lead Quality Control activities for clinical and commercial small-molecule drug substance and drug product programs. Manage specifications, stability studies, reference standards, analytical testing, OOS/OOT investigations, release documentation, CMC submission reviews, external laboratories, CMOs, audits, quality systems, and sample transfers. Collaborate across CMC, QA, API, and drug product teams, provide technical development support, and lead team capacity, performance, and deliverables. Domestic and international travel may be required.

Lead Quality Control activities for clinical and commercial small-molecule drug substance and drug product programs. Manage specifications, stability studies, reference standards, analytical testing, OOS/OOT investigations, release documentation, method validations, CMC submission reviews, external laboratories, CMOs, audits, and quality systems. Collaborate across CMC, QA, API, and drug product teams while leading assigned staff and supporting regulatory and commercial readiness. Up to 20% domestic and international travel is required.

The Executive Director, Total Rewards will manage and design compensation strategies, ensuring alignment with business goals, compliance, and market competitiveness to retain top talent in North America.

The Executive Director, Total Rewards will lead total compensation strategies to attract and retain talent, managing salary, benefits, and recognition programs in a strategic HR role.

The Senior Manager will oversee regulatory submission processes, manage external publishing vendors, support project teams, maintain regulatory calendars, and enhance operational functions within the Regulatory Affairs department.

Leads enterprise data integration and engineering capabilities, including APIs, middleware, ELT pipelines, data governance, master data management, and cloud analytics platforms. Designs secure, compliant integrations across ERP, CRM, clinical, research, quality, finance, and commercial systems. Establishes architecture standards, data quality controls, monitoring, validation, and support processes while coordinating internal engineers, vendors, and business stakeholders. The role also provides technical leadership for trusted datasets, regulatory compliance, operational reliability, and commercialization readiness.

The Manager/Senior Manager will lead data management for clinical trials, oversee vendors, design databases, and ensure compliance with regulations.

The Manager/Senior Manager will lead data management activities for clinical trials, collaborating across functions to design databases and manage vendors, while ensuring compliance with regulations.

Leads operational delivery of multiple Phase 3 clinical trials from startup through closeout. Responsibilities include vendor and CRO selection and oversight, site feasibility, budgets, timelines, risk mitigation, regulatory documentation, cross-functional collaboration, investigator selection, trial metrics, and adherence to ICH/GCP and applicable regulations. The role also mentors staff and supports process improvements and best practices.

Leads revenue recognition and Gross-to-Net accounting under ASC 606, including reserves, monthly close, forecasting, government pricing, reconciliations, and variance analysis. Builds scalable commercial accounting systems, data flows, SOX-compliant controls, policies, and procedures for commercial launch. Partners with Commercial, auditors, vendors, and executives on pricing strategy, financial reporting, guidance, and business performance insights.

Develop and execute internal communications strategies and multi-channel programs to build culture and align employees with company mission. Create content for intranet, companywide emails, town halls, and leadership meetings. Lead planning and execution of large- and small-scale corporate events and leadership offsites, manage vendors, budgets, contracts, and invoices. Partner with stakeholders globally to drive engagement, brand consistency, and process improvements. Support Corporate Affairs initiatives and occasional international travel; role is hybrid based in Vancouver with in-office event responsibilities.

Lead development and execution of corporate, investor, executive and R&D communications. Craft messaging, press releases, SEC filing support, earnings calls, IR materials, and executive visibility programs. Coordinate across Finance, Legal, R&D, and Commercial; manage IR events, investor meetings, website content, competitor monitoring, budgets, and stakeholder relations. Support issues management and investigator communications. Travel up to 15%.

Leads operational delivery of multiple Phase 3 clinical trials from start-up through closeout. Responsibilities include vendor and CRO selection and oversight, site feasibility, budgets, timelines, risk mitigation, regulatory documentation, cross-functional coordination, compliance with ICH/GCP and applicable regulations, and mentoring junior staff. The role manages trial milestones, quality, and outsourced services while partnering with Clinical Development, Regulatory Affairs, CMC, investigators, and external vendors.

Provide administrative and project coordination for Discovery teams; manage ingestion, organization, and distribution of externally generated scientific data into ELN and enterprise systems; maintain records and inventories; support lab and meeting logistics; collaborate with IT and scientific teams to improve workflows and ensure compliance and safety.

Provide scientific leadership for clinical study design, execution, analysis, and reporting across assigned neuroscience programs. Support protocol development, safety and efficacy data review, regulatory documentation, cross-functional collaboration with CROs and partners, investigator interactions, and development of SOPs and study materials to ensure scientifically rigorous, operationally feasible clinical development.

Lead scientific contribution to design, execution, analysis, and interpretation of clinical trials for neuroscience programs. Draft and review clinical and regulatory documents, collaborate cross-functionally and with CROs/investigators, monitor safety and efficacy data, perform literature review, support study start-up and training, and help develop development strategies, SOPs, and scientific communications.

Lead commercial data management for a pre-launch/launch biotech product: build governed commercial data ecosystem, own MDM for HCP/HCO/payer identities, manage data quality and stewardship, coordinate vendors and data platforms, translate business needs to data requirements, and enable reporting-ready datasets to support analytics and launch decision-making.