Jobs at Xenon Pharmaceuticals Inc.

Provides administrative, scientific data management, documentation, inventory, and project coordination support for Discovery operations. Responsibilities include managing calendars, travel, expenses, scientific data uploads, ELN records, reports, inventories, digital workflows, stakeholder communications, and laboratory compliance. The role coordinates with scientific, IT, and operational teams to improve data accuracy, accessibility, and process efficiency in a biopharmaceutical discovery environment.

Serves as the strategic HR Business Partner to Commercial Sales and Marketing leadership. Leads workforce planning, organizational design, talent strategy, sales hiring, onboarding, employee engagement, performance management, succession planning, and organizational development. Acts as HR lead for launch readiness, coordinating Talent Acquisition, Total Rewards, HR Operations, Learning and Development, Compliance, and Legal. Advises leaders through rapid growth, commercialization, organizational change, and infrastructure development while supporting an inclusive, high-performing culture.

Provides GCP and GLP quality assurance support for early-stage clinical programs, including quality planning, risk assessments, audits, inspection readiness, compliance consultation, training, CAPA evaluation, root cause analysis, and regulatory inspection support. Collaborates with cross-functional stakeholders to identify and escalate quality issues, maintain data integrity, and advance GLP/GCP quality strategies across pharmaceutical R&D programs.

Lead Quality Control activities for clinical and commercial small-molecule drug substance and drug product programs. Manage specifications, stability studies, reference standards, analytical testing, OOS/OOT investigations, release documentation, CMC submission reviews, external laboratories, CMOs, audits, quality systems, and sample transfers. Collaborate across CMC, QA, API, and drug product teams, provide technical development support, and lead team capacity, performance, and deliverables. Domestic and international travel may be required.

Lead Quality Control activities for clinical and commercial small-molecule drug substance and drug product programs. Manage specifications, stability studies, reference standards, analytical testing, OOS/OOT investigations, release documentation, method validations, CMC submission reviews, external laboratories, CMOs, audits, and quality systems. Collaborate across CMC, QA, API, and drug product teams while leading assigned staff and supporting regulatory and commercial readiness. Up to 20% domestic and international travel is required.

The Executive Director, Total Rewards will manage and design compensation strategies, ensuring alignment with business goals, compliance, and market competitiveness to retain top talent in North America.

The Executive Director, Total Rewards will lead total compensation strategies to attract and retain talent, managing salary, benefits, and recognition programs in a strategic HR role.

Leads enterprise data integration and engineering capabilities, including APIs, middleware, ELT pipelines, data governance, master data management, and cloud analytics platforms. Designs secure, compliant integrations across ERP, CRM, clinical, research, quality, finance, and commercial systems. Establishes architecture standards, data quality controls, monitoring, validation, and support processes while coordinating internal engineers, vendors, and business stakeholders. The role also provides technical leadership for trusted datasets, regulatory compliance, operational reliability, and commercialization readiness.

Lead development and execution of corporate, investor, executive and R&D communications. Craft messaging, press releases, SEC filing support, earnings calls, IR materials, and executive visibility programs. Coordinate across Finance, Legal, R&D, and Commercial; manage IR events, investor meetings, website content, competitor monitoring, budgets, and stakeholder relations. Support issues management and investigator communications. Travel up to 15%.

Lead Quality Control for clinical and commercial drug substance and product programs, managing analytical testing, release and stability programs, reference standards, specifications, OOS/OOT investigations, vendor/CMO oversight, regulatory CMC QC content, audits, and cross-functional collaboration to ensure cGMP and ICH compliance.

Lead design, build, and execution of Xenon’s U.S. commercial sales organization. Define field structure, hire and develop national sales leadership and reps, set performance frameworks, partner cross-functionally (Marketing, Market Access, Medical Affairs, Ops, Legal), drive launch readiness and execution, manage budgets, and use data to optimize targeting and resources. Support KOL engagement, payer strategy, and compliant sales operations.

Lead and coordinate Discovery-stage small molecule programs, manage CROs and contracts, maintain project schedules/budgets, facilitate cross-functional alignment, oversee data workflows and preclinical reporting, and support scientific communications and disclosure processes.

Lead Quality Control for drug substance and product programs from clinical through commercial stages: manage analytical testing, stability programs, reference standards, specifications, OOS/OOT investigations, release and regulatory CMC QC inputs, external lab/CMO oversight, audits, cross-functional collaboration, and supervise staff as needed. Travel up to 20%.

Lead payer engagement for the West region to secure rapid formulary coverage and access parity for Xenon products. Build and maintain strategic payer relationships, develop account plans, negotiate contracts, align with Medical Affairs and Value & Access, support field pull-through and training, deliver payer insights, manage budgets, recruit and coach staff, and represent Xenon at industry conferences. Some international travel may be required.

Lead development and execution of US HCP education strategy to support brand and launch objectives. Design and run peer-to-peer programs, congress strategy, digital learning, workshops and advisory boards. Integrate cross-functionally with Medical, Sales, Market Access, and Compliance. Manage KOLs, agencies, budgets, KPIs, and analytics to drive HCP adoption and launch readiness.

Lead U.S. payer market access for Azetukalner, building relationships with national/regional payers, securing formulary coverage and contracting, developing account strategies, collaborating with Commercial, Medical Affairs, and HEOR, supporting field teams, and representing Xenon at industry conferences to ensure rapid patient access.

Lead implementation, configuration, and day-to-day operations of Quality and Supply Chain IT systems (Veeva, iStability, Oracle Fusion, SAS, Egnyte). Partner with stakeholders and vendors, author and review SDLC deliverables, manage integrations/APIs, perform system administration, user/licensing management, onboarding/training, vendor relationships, change control, and ensure compliance with company IT processes.