Teams at Wave Life Sciences

Lead preclinical safety assessment for therapeutic oligonucleotides, design and oversee exploratory and GLP toxicology studies, provide risk assessment and de-risking strategies, coordinate with cross-functional teams and CROs, interpret PK/PD and animal model data, author/review nonclinical regulatory documents, and guide program and regulatory strategy.

Provide clinical leadership for assigned products across all development phases. Design, plan, and oversee clinical trials; ensure scientific integrity, regulatory compliance, and medical oversight. Collaborate with cross-functional teams and external vendors, interpret and disseminate study results, support translational medicine, represent the company to regulators and at scientific forums, and mentor/manage staff as needed.

Designs, executes, and interprets in vitro and in vivo ADME/PK/PKPD, TK, PPB and DDI studies for RNA therapeutics. Analyzes PK/TK data (NCA), manages internal and CRO DMPK activities, contributes to IND/CTA regulatory packages, and represents DMPK on cross-functional teams.