Jobs at Topos Bio

Develops and optimizes mammalian cell-based assays for intrinsically disordered protein targets, executes phenotypic and reporter screening campaigns, characterizes compound activity, and supports structure-activity relationship studies. The role collaborates with computational scientists, establishes assay protocols and quality metrics, and applies disease-relevant cellular models to drug discovery in oncology, neurodegeneration, and cardiometabolic disease.

Develop and optimize machine learning methods for intrinsically disordered proteins, including generative models for protein conformational ensembles, affinity prediction, and generative chemistry. Build scalable training pipelines, adapt research methods, and collaborate with computational and experimental scientists to validate models using biophysical data.