Teams at Substrate Bio

Lead and build an end-to-end functional genomics vertical: scope and validate screening workflows (cell line engineering, perturbation libraries, pooled and single-cell sequencing), hire and manage scientists and technicians, co-design automation-ready protocols with engineering, and collaborate with foundation model partners to produce structured datasets for model training. Own quality thresholds, validation, customer engagements, and roadmap execution during manual, instrumented, and autonomous phases.

Lead and build Substrate's finance function end-to-end: controllership (close, payroll, audit), FP&A and financial modelling, cap table and debt management, CAPEX accounting, and designing usage-based pricing tied to billing and revenue recognition. Partner with founders on fundraising and commercial decisions, operationalise pricing with customers, and scale the finance team and systems.

Develop and validate end-to-end protein production workflows (DNA design, expression, purification, QC) by hand, build reproducibility and acceptance criteria, co-design automation-ready protocols with engineering/software teams, transition validated assays onto instrumentation, author SOPs, and support scale-up and team growth.