Jobs at Spyre Therapeutics

Manage outsourced bioanalytical and biomarker activities for clinical programs, including pharmacokinetic, immunogenicity, and pharmacodynamic assays. Coordinate CROs, oversee assay development and validation, review protocols and data packages, plan clinical sample analysis, investigate issues, evaluate trends, and contribute to regulatory documentation while ensuring scientific quality, data integrity, compliance, and timely delivery.

Lead end-to-end clinical supply chain operations for global studies, including demand forecasting, inventory and resupply planning, IRT strategy, packaging and labeling coordination, global distribution, country activation, import/export documentation, customs, reverse logistics, and vendor oversight. Partner cross-functionally with CMC, Clinical Operations, Quality, Regulatory, CROs, and CDMOs while managing budgets, risks, KPIs, and continuous improvement for compliant and uninterrupted clinical supply.

Physician leader responsible for strategic and operational oversight of IBD antibody clinical development. Lead the Phase 2 platform trial, drive protocol development, medical review, safety oversight, data interpretation, and regulatory interactions. Partner cross-functionally to design and execute trials, chair governance committees, mentor clinical teams, and shape registrational strategy and program-level decisions.