Jobs at Cytokinetics

Leads preclinical pharmacology research across cardiac and muscle biology programs. Designs and executes complex in vivo studies, oversees dosing and biochemical or molecular assays, evaluates biomarkers and compound efficacy, and informs development decisions. Collaborates cross-functionally to advance compounds, presents findings, contributes to publications and patents, and mentors scientific staff. Requires expertise in rodent studies, cardiac functional assessments, and molecular biology assays.

Lead sourcing and supplier relationship management for CMOs, labs and critical suppliers across development through commercialization. Drive supplier selection, RFIs/RFPs, contract negotiations, performance monitoring, risk mitigation, audits, and cross-functional collaboration with CMC, Technical Operations, Procurement, Legal, Quality, and global teams.

Lead statistical genetics analyses (GWAS, fine-mapping, Mendelian randomization) and multi-omics integration to identify and prioritize genetic targets for cardiovascular and muscle diseases. Develop bioinformatics pipelines, manage large-scale genomic and clinical datasets, design AI/ML phenotyping methods, collaborate with biologists and clinicians, and communicate findings in publications and regulatory documents.

Lead statistician providing statistical leadership for clinical development and study design, SAPs, DMC coordination, regulatory submissions, exploratory analyses integrating multimodal data, mentoring staff, and advancing AI/ML-enabled insights across clinical programs.

Provide high-level, confidential administrative and operational support to the CFO and CFO organization, managing complex calendars, Board and audit materials, travel, meetings, executive communications, and special projects while handling sensitive financial and corporate information with discretion.

Serves as the strategic finance partner to Commercial leadership, leading budgets, forecasts, long-range planning, operating expense and headcount management. Performs variance analysis, evaluates commercial investments and launch decisions, develops financial models and business cases, and advises executives on risks, opportunities, and resource allocation. Builds scalable planning infrastructure, dashboards, and forecasting processes while preparing executive and Board-level analyses and presentations.

The Senior Director, FP&A leads financial planning and analysis, advising on strategic goals, managing budgets, and mentoring staff within a biopharmaceutical context.

Leads enterprise strategy, business development analytics, drug revenue forecasting, valuation modeling, strategic planning, executive and board analyses, and the company’s AI initiative. Builds commercial forecasts from epidemiology, pricing, diagnosis, treatment, and uptake assumptions; develops rNPV, DCF, scenario, sensitivity, and transaction models; supports portfolio decisions and deal evaluations; coordinates AI governance and adoption; and delivers decision-ready recommendations to senior leadership and the Board.

Conduct preformulation assessments and develop formulations for poorly water-soluble small molecules supporting preclinical PK, pharmacology, and toxicology studies. Lead solid-form screening, solubility and stability testing, dissolution studies, and HPLC/UPLC method development. Manage laboratory timelines and contract research organizations, support candidate selection and first-in-human documentation, and author technical reports for CMC and regulatory use. Collaborate with cross-functional discovery, CMC, biology, chemistry, and pharmacokinetics teams.

Lead pricing governance, contracting, and market access analytics for GVAD. Develop deal modeling, performance dashboards, channel and distribution analyses, and actionable insights to inform contracting, revenue/rebate forecasts, and cross-functional decision-making.

Lead QA oversight for drug substance and drug product manufacturing and testing performed by CMOs/CTLs. Manage a QA team, approve batch records and GMP documents, oversee investigations/CAPAs, support inspections and audits, drive technology transfers, process validation, supplier oversight, and continuous improvement to ensure global regulatory compliance and product quality.

The Senior Manager, Quality Compliance leads quality compliance activities, overseeing product complaint handling, regulatory inspections, and quality processes while collaborating with cross-functional teams.

The Senior Director, CMC Lead will oversee product development strategy, leading CMC programs, and ensuring effective communication and governance across teams to support drug development and regulatory approval.

The Director of Operational Excellence will lead process improvement initiatives and enhance operational efficiency in Supply Chain and Manufacturing, ensuring high-quality medicine delivery. This role requires collaboration with stakeholders and expertise in Lean methodologies.

Lead development and execution of internal communications strategies and campaigns to inform and engage employees globally. Own the intranet and employee channels, support executive and HR communications, manage content, digital signage, office branding, swag, event photography, and vendor partnerships to strengthen culture and employee experience.

Lead enterprise Business Process Management for Global Supply Chain & Technical Operations: design end-to-end process architecture, govern process lifecycle, drive process performance and continuous improvement, enable inspection readiness and scalability, establish governance and KPIs, partner with Operational Excellence, IT, and functional leaders, and lead change adoption across Plan, Source, Make, Deliver, and Enable value streams.

Lead pricing governance, contracting, and market access analytics for GVAD. Develop deal models, financial analyses, and performance dashboards; monitor channel and payer metrics; support B2B negotiations and contracting operations; validate distribution and specialty pharmacy data; drive process and system improvements; and brief leadership and cross-functional teams to inform pricing and access strategy.

Lead design and scale-up of small-molecule manufacturing routes, optimize reactions and processes, support tech transfer and CDMO collaboration, characterize materials using HPLC/LC-MS/NMR, maintain cGMP-compliant records, prepare technical reports and regulatory filings, and mentor junior scientists within cross-functional project teams.

Lead REMS strategy and operations to ensure regulatory compliance while optimizing patient access and provider experience. Manage REMS compliance, audits, CAPA remediation, REMS assessments and submissions, vendor relationships, REMS portal platform, training, KPI development, and cross-functional collaboration to improve program outcomes and patient onboarding.

Lead end-to-end tactical global supply planning for assigned pharmaceutical brands. Own E2E brand plans, drive S&OP, resolve demand-supply imbalances, manage inventory and KPIs, mitigate risks, and collaborate cross-functionally with quality, regulatory, commercial, finance, and external manufacturers to ensure compliant, cost-effective supply operations.