Choosing between a small startup and a large company is like choosing choosing between the eclectic flavors of a local food truck and the classic menu at The Piccadilly; both are satisfying but offer very different experiences. While smaller companies often provide a hands-on, flexible environment, large companies bring stability, structure and often more robust benefits to the table.
In St. Louis, it’s no different. For those leaning toward the security and resources that come with working at a company established in both time and size, the city is home to several delivering just that.
Largest Companies in St. Louis
- Mastercard
- CrowdStrike
- Wipfli
- Pfizer
- ServiceNow
- Edward Jones
- Grainger
- Berkshire Hathaway
- Emerson
- Boeing
Largest Companies in St. Louis to Know
Wipfli provides services such as audit and assurance, tax and outsourced finance to a variety of clients. The company has more than 50 offices globally and employs thousands of people full time. It hires for remote and hybrid roles near its regional locations.
Grainger supplies both public and private sector clients with industrial and safety products and offers services such as technical support and facility maintenance. The company’s St. Louis branch is located downtown on Clark Avenue.
Cybersecurity company CrowdStrike safeguards endpoints, cloud systems and data using its AI-driven Falcon platform. With a global workforce of tens of thousands, the company operates a regional office in the greater St. Louis area.
Berkshire Hathaway began as a textile manufacturer and has grown into a multinational holding company with subsidiaries such as GEICO, BNSF Railway and others across various industries. Headquartered in Omaha, Nebraska, the company operates in multiple sectors throughout Missouri and around the world.
Boeing designs, builds and services commercial airplanes, defense systems and space technologies for customers worldwide. In Missouri, its workforce is involved in developing next-generation aircraft, training programs and defense systems, and the company announced an expansion to its local operations with the addition of a $1.8 billion facility.
What started as a one-room brokerage in St. Louis, Edward Jones has expanded to serve nearly 7 million clients through more than 15,000 branch offices across North America. The firm aims to enable long-term financial planning through a personalized approach and strong advisor-client relationships.
ServiceNow provides a platform that helps businesses automate and manage internal operations by linking departments and systems. In 2024, the company reported just under $3 billion in subscription revenue, and it employs tens of thousands of people at locations including its Missouri office in Chesterfield.
Emerson offers products such as industrial automation equipment and climate control systems, and its services support customers across industries in improving productivity and sustainability. As of 2023, the company’s new global headquarters is located in the Clayton area of St. Louis.
Mastercard ranks among the largest global payment processors, enabling electronic transactions across the world through its extensive network of branded credit, debit and prepaid cards. With a presence in over 100 locations internationally, one of its key technology hubs is located in O’Fallon, Missouri.
Pfizer, one of the world’s largest pharmaceutical companies, manufactures prescription medications as well as over-the-counter drugs, treatments and vitamins for global distribution. In St. Louis, the company says it operates a 250,000-square-foot laboratory and manufacturing facility that’s focused on biotherapeutics and vaccine development.
