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Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.
RESEARCH ASSOCIATE/ ASSOCIATE SCIENTIST, NONCLINICAL DEVELOPMENT
Key responsibilities:
- Coordinate and execute in vivo and ex vivo nonclinical studies to evaluate Adicet’s immune-cell and gene-therapy platforms, including efficacy, pharmacokinetic/pharmacodynamic, and safety assessments in relevant murine oncology and immunology models.
- Contribute to study design, experimental planning, timeline development, and data-driven decision-making to support program advancement.
- Collaborate and communicate effectively with cross-functional teams and external contract research organizations to coordinate study execution, troubleshoot technical challenges, and ensure study endpoints align with program objectives
- Perform necropsies and process tissues for downstream analyses, including flow cytometry, qPCR/ddPCR, and ELISA, to characterize pharmacologic activity and elucidate mechanisms of action.
- Maintain accurate, complete, and well-organized experimental records in accordance with internal documentation and quality standards.
- Bachelor’s degree in biological sciences or a related field with 5+ years of relevant R&D experience, or a Master’s degree with 3+ years of experience, preferably in immuno-oncology, within an industry setting.
- Significant experience designing, executing, analyzing, and interpreting in vivo studies using murine xenograft disease models and/or humanized immunology models.
- Demonstrated proficiency administering therapeutic agents and establishing xenograft models through intravenous, intraperitoneal, and subcutaneous routes in mice.
- Strong technical proficiency in blood collection, including submandibular and tail-vein sampling, as well as tissue necropsy and sample processing for flow-cytometry applications.
- Experience with aseptic mammalian cell culture, including the maintenance and preparation of human cancer cell lines for nonclinical in vivo studies.
- Hands-on experience with in vivo bioluminescence and/or fluorescence imaging, including image acquisition and data analysis using IVIS platforms.
- Experience with laboratory techniques such as flow cytometry, ELISA, qPCR/ddPCR, and cytokine bead-based assays is preferred.
- Excellent organizational, communication, data-analysis, and technical-documentation skills.
- Demonstrated ability to work independently, troubleshoot scientific and technical challenges, and contribute innovative solutions.
- Ability to manage multiple priorities and thrive in a fast-paced, collaborative, and supportive research environment.
Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.
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Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.
At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting autoimmune diseases and cancer.
We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.
To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs.
We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 13 company holidays, paid end-of-year winter break, vacation, sick time, and paid parental leave.
Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company-subsidized lunches (delivered onsite daily) and fully stocked breakrooms.
Adicet is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
Skills Required
- Bachelor's degree in biological sciences with 5+ years R&D experience, or Master's degree with 3+ years experience
- Significant experience designing, executing, analyzing, and interpreting in vivo studies using murine xenograft and/or humanized immunology models
- Proficiency administering therapeutic agents and establishing xenograft models via intravenous, intraperitoneal, and subcutaneous routes in mice
- Technical proficiency in blood collection (submandibular, tail-vein), necropsy, and tissue processing for flow cytometry
- Aseptic mammalian cell culture experience, including maintenance and preparation of human cancer cell lines for in vivo studies
- Hands-on experience with in vivo bioluminescence and/or fluorescence imaging and IVIS platform image acquisition and analysis
- Experience with flow cytometry, ELISA, qPCR/ddPCR, and cytokine bead-based assays
- Experience in immuno-oncology within an industry setting
- Excellent organizational, communication, data-analysis, and technical-documentation skills
- Ability to work independently, troubleshoot technical challenges, manage multiple priorities, and contribute solutions
What We Do
At Adicet (Nasdaq: ACET), we are defined by our mission to deliver best-in-class gamma-delta T cell therapies for patients fighting cancer. Every one of our team members, whether in the lab, manufacturing, or general business role, comes to work every day with the patient in mind. As pioneers in the cell therapy space, we are honored and humbled by the opportunity to put our talents to bear in developing transformative therapies to defeat cancer. We believe that the best way to do this is through discovering and developing allogeneic gamma-delta T cell therapies, a novel type of cell therapy. Adicet has chosen the gamma-delta T cell because it has multiple ways to target and kill cancer cells, which may provide a better chance of achieving complete and durable responses to therapy. Additionally, instead of using cells from the already sick cancer patient, Adicet uses cells from unrelated donors (allogeneic) because they are reliable and readily available allowing us to rapidly and cost-effectively scale production of these medicines and make them available when needed (“off-the-shelf”). Specifically, as a clinical stage biotechnology company we are advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CAR) and T cell receptor-like antibodies (TCRL) to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and improve persistence for durable activity in patients.
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