Sr. Principal Scientist - Discovery Radiochemistry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. For more than 140 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges.

Position Summary:

The individual will be supporting the discovery program by developing both therapeutic and diagnostic radiolabeling processes and ensuring supply of materials.  The individual will work collaboratively with internal team members and external partners to enable the supply of radiolabeled compounds for preclinical experiments.

Responsibilities:

• Develop radiochemistry processes and formulations.
• Develop suitable analytical testing methods to characterize research batches.
• Produce, test, and supply radiolabeled compound batches to support preclinical evaluation of radiolabeled compounds internally/externally.
• Transfer radiochemistry and testing methods to team members and external partners. 
• Train internal colleagues or external partners on radiochemistry processes and associated methods. Provide onsite/remote technical support to external partners as needed
• Prepare and deliver presentations for internal and external team meetings
• Author applicable laboratory notebook entries, development reports, manuscripts for publication in journals and patents
• Other duties as assigned

Basic Requirements:

• BS/MS in organic chemistry, chemistry or a related discipline and 5+ years of relevant radiochemistry experience or PhD degree in organic chemistry, coordination/inorganic chemistry or radiochemistry.
• Proven ability to work independently with strong organization and excellent written/verbal communication skills
• Demonstrated ability to successfully prioritize projects and manage timelines in a fast-paced environment

Additional Preferences:

• Previous working experience in radiochemistry environment
• Hands on experience with imaging radioisotopes (F-18, Ga-68, Cu-64, In-111, Zr-89) and/or therapeutic radioisotopes (Lu-177, Ac-225, Pb-212, Tb-161) is considered an asset
• Experience in quality control testing of radiolabelled compounds (hands-on experience with radio-HPLC-MS, radio-ITLC) is considered an asset
• Knowledge of environmental health and radioprotection requirements
• Good working knowledge of multiple automated radiosynthesizer
• Functional Knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines

Physical Demands/Travel:

• Requires up to 20% of travel nationally and internationally. A valid passport and eligibility to travel into these countries are required.
• Requires ability to lift up to 30 kg
• Requires safety shoes and other personal protective equipment at applicable work area

 The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

• This position’s work environment is in a Laboratory. Position requires to be onsite during the work week.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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