The Sr. Consultant will design polycistronic mRNA constructs, optimize mRNA sequences, implement novel methods, and contribute to regulatory filings.
Summary Generated by Built In
Sr. Consultant / mRNA Engineering
Location: Remote / On site as needed
Position: Part-time
Reports to: CSO
Job Description
GenEdit is a rapidly growing, early-stage company that is developing a proprietary and novel delivery platform with the potential to transform genetic medicine. Our interdisciplinary team works together across chemistry, payload, formulation, screening, and preclinical groups to develop the next generation of gene therapies. GenEdit fosters an exciting and dynamic environment where we value impactful data and creative solutions to accelerate our progression from platform technology to a pipeline of therapeutic candidates.
We are seeking a Sr. Consultant with deep expertise in mRNA engineering, more specifically design of polycistronic mRNA constructs, to help our cross-functional discovery teams and create novel drug candidates.
Key Responsibilities
· Design and polycistronic mRNA encoding multiple protein/peptide antigens.
· Design and optimize mRNA sequences including 5′ and 3′ untranslated regions (UTRs) and open reading frames (ORF) to enhance mRNA's stability, translation efficiency, and ultimately, therapeutic effect.
· Use mRNA design software to support mRNA design workflows and to analyze data and predict the behavior of designed mRNA constructs.
· Implement novel methods for mRNA modifications to improve its therapeutic potential.
· Generate intellectual property and contribute to regulatory filings.
· Keep up-to-date with new technologies, industry trends, and research in mRNA science.
Qualifications
· PhD degree in molecular biology or a closely related discipline with 10+ years of experience
· Extensive experience in mRNA design, including expertise in designing, modifying, and optimizing polycistronic mRNA constructs.
· Proficiency with computational tools, including relevant software, algorithms, and databases for mRNA design and analysis.
· Industry experience in mRNA design or related areas is highly preferred
· Ability to analyze and interpret complex data from experiments and computational analysis.
· Excellent written and verbal communication skills
At GenEdit we are always looking to hire the absolute best talent and recognize that diversity in our experiences and backgrounds is what makes us stronger. We hire candidates of any race, color, ancestry, religion, sex, national origin, sexual orientation, gender identity, age, marital or family status, disability, veteran status, and any other status. These differences are what enable us to work towards the future we envision for ourselves, and the world.
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