About Third Harmonic Bio
Third Harmonic Bio is a biopharmaceutical company with a singular purpose: To create a breakthrough treatment for people living with severe allergy and inflammation – debilitating conditions that can take a significant toll on overall health and well-being.
We are developing a highly selective oral wild-type KIT inhibitor for millions of people living with chronic urticaria, severe asthma, and other mast cell-mediated diseases. Despite the availability of multiple approved medicines, there is an urgent need for new treatment options. We are grounded in our purpose of developing medicines to meaningfully improve the lives of the patients we serve.
We are seeking smart, fun, and talented individuals seeking a fast-paced environment where they can meaningfully contribute to building a successful company.
Our Values
Our values provide the foundation for our culture and our operating principles – and underly how we hold ourselves accountable and how we interact with each other, with our partners, and with the global medical and patient community.
Be Human
Relationships are important. Bring your full self to work and create space for others to do the same. Balance candor with empathy.
Own the Big Picture
Context is critical. Ground every decision and action in the entirety of what we are trying to achieve.
Go THRD
We hold ourselves to a higher standard. Work with urgency, purpose, and passion.
The Role
Reporting to the VP, Biology, the Senior Scientist, In Vitro Pharmacology will perform in vitro pharmacology activities supporting traditional small molecule inhibitors, heterobifunctional degraders, and biologics/large molecule programs. Initially, this role will be responsible for managing CRO and other external pharmacology activities. Eventually the role will also be responsible for developing and executing in vitro and cell-based assays in support of discovery and lead optimization programs. This is a great opportunity to collaborate with cross-functional colleagues in driving our programs to success and growing our pipeline.
Responsibilities
- The primary responsibilities of the In Vitro Pharmacology Scientist will be to support our early drug discovery programs through the design, development and performance of in vitro and ex vivo cellular and/or biochemical assays
- In addition, managing CRO-based in vitro pharmacology activities
- Independently develop, perform, interpret, and troubleshoot a broad range of in vitro assays including immune cell profiling in blood and tissues, functional assays using cell lines and primary or cultured cells
- Innovate and expand our assay portfolio by identifying, evaluating, and implementing new assay technologies through literature research, academic collaborations, and adaptation from other groups within the company
- Effectively present internally at team and departmental meetings and externally to collaborators and scientific communities
- Stay updated with cutting edge discoveries and trends and contribute to the company’s R&D strategy to generate and test actionable development plans
- Contribute to work with external parties, including academic collaborators and CROs to create comprehensive capabilities for MoA, target validation and potency studies
- Write clear and concise research reports and ensure study documentation and update protocols to ELN
Minimum Qualifications
- PhD or MS in related field and 5-7 years of industry experience, including experience in pharmacology, cell biology, biochemistry, or related discipline
- Technical proficiency with cellular and biochemical assays including assay design, development and validation in support of immunology-based targets
- Proficient in cell culture and cell imaging, such as stable cell line generation and maintenance, high content imaging or flow cytometry
- Hands on ability to execute wet lab experiments, data processing, and ability to effectively communicate key scientific findings across the organization
- High attention to detail with strong data analysis and interpretive skills
- Excellent communication and interpersonal skills
- Collaborative mindset and willingness to work effectively as part of a cross functional team
- Experience in the drug discovery process, supporting discovery, lead optimization, and candidate selection and knowledge of immunology would be a plus
The approximate salary range for this role is $155,000-175,000.
All qualified applicants will receive consideration for employment without regard to race, sex color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.
What We Do
Third Harmonic Bio is a clinical-stage biopharmaceutical company developing a highly selective, oral KIT inhibitor for treatment of dermal, respiratory and gastrointestinal inflammatory diseases. KIT is a cell surface receptor that acts as the master survival and functional regulator of mast cells, which are immune cells concentrated at the body’s interfaces with the external environment and that act as the key mediator of the inflammation associated with mast-cell mediated inflammatory diseases. By inhibiting KIT, we believe we can provide broad symptomatic relief to patients with a range of disorders, including chronic spontaneous urticaria and severe asthma
