Senior Scientist, AMP-Seq Team Lead

Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just "treat" people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

Senior Scientist, AMP-Seq Team Lead

We seek a Senior Scientist to lead the amplicon sequencing (AMP-Seq) team within the Genomics Innovation group. Genomics Innovation provides advanced genomics solutions, ranging from screening of editing modalities, to developing and implementing a diverse toolbox of sequencing assays for the characterization of genome editing outcomes. This dynamic role integrates team management in leading the AMP-Seq team and a labwork component in leveraging NGS expertise to explore and develop genomics applications with groups across the company.

AMP-seq is state of the art and operates on an industrial scale, processing tens of thousands of samples every month. It is central to the development of our genome editing technologies and builds the foundation of our diverse range of internal and external partner programs, advancing potentially life changing CRISPR/Cas9-based therapeutics. With a combination of genomics assay development ability, team leadership skills, and hands on NGS library prep and sequencer operation expertise, this role will generate opportunities to work together with research and early development teams, exploring a wide range of gene editing applications.

In this role, you will:

• Lead a team of junior scientists responsible for running a high throughput Illumina amplicon sequencing workflow as well as smaller scale PacBio amplicon workflow
• Chart the course for the future of AMP-Seq (e.g. process optimization, new automation workflows)
• Ensure timely data delivery, working with automation and informatics teams to promptly address run failures, and work with collaborators to communicate updates and troubleshoot submissions
• Apply NGS subject matter expertise to develop and support new projects and applications in Genomics
• Explore and experimentally test new sequencing technologies, such as new short read sequencing platforms, duplex sequencing, and long read sequencing applications
• Evaluate and implement new sequencing assays for characterizing gene editing outcomes, drawing on new published methods , new commercial kits, and internal assay development to answer emerging research questions
• Present your or the team's work at project and larger team meetings

About You:

The successful candidate will have demonstrated deep expertise in Illumina NGS technology and molecular biology. The candidate should have biotech/pharma industry experience, some direct management experience, and exposure to liquid handling automation.

• PhD in Genomics or related field with 2-5 years of directly relevant experience (industry experience strongly preferred)
• Solid hands-on experience with Illumina library construction, quantification, instrument operation (NextSeq2000 preferred), troubleshooting, and expert level NGS knowledge
• Experience directly managing junior scientists
• Track record of developing, optimizing, and implementing NGS-based assays
• Experience with running and optimizing liquid handling automation (Hamilton) is preferred
• Experience with genome editing technologies (e.g. CRISPR) is preferred
• Strong communication and documentation skills, coupled with exceptional time management skills and attention to detail

Meet your future team:

The team is focused on NGS applications for research and early development at Intellia. The focus is to predominantly support the development of new editing platforms, screening for new lead drug candidates, and evaluating drug candidate off-target editing profiles, in addition to supporting a wide range of other projects. The team is working onsite to execute NGS workflows in a wet-lab environment. Therefore, we require a candidate to be local to Cambridge MA, or open to relocating. Our team is focused on reliably delivering AMP-Seq data, improving the AMP-Seq process, and exploring innovative genomics solutions for emerging questions. In this role, you can expect to join a team of hardworking, supportive, and curious scientists in a collaborative environment.

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.