A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 45 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
The Sr. Scientific Manager will help drive and execute our strategy for the adoption and use of blood-brian-barrier (BBB) models across the company and development portfolio. In particular, they will be responsible for aligning our model development and validation efforts across the REDs, representing Genentech in external consortia developing blood-brain-barrier modeling technologies, and driving internal adoption of blood-brain barrier modeling technologies in our pharma pipeline. In addition, this position will also be responsible for a portion of routine data generation, including generating data to support project teams, training scientists on usage of in vitro BBB models, and maintaining general laboratory upkeep tasks. Due to combined needs across strategic management, stakeholder organization, and in-laboratory skills, this position requires a candidate with strong organizational, multi-tasking, and communication skills, and must feel comfortable in a fast-paced and diverse research environment.
The Opportunity:
As an integral member of our dynamic team, you will:
Drive momentum in New Approach Methodologies (NAMs), and collaborate internally across research and development functions to drive adoption of BBB NAMs in our portfolio projects.
Join a team of leading scientists driving momentum in New Approach Methodologies (NAMs), and collaborate internally across research and development functions to drive adoption of BBB NAMs in our portfolio projects.
Gain exposure to internal molecule development teams and participate by generating data to contribute to molecule progression.
Develop external presence and influence by representing Genentech in relevant external consortia on NAM technologies and help guide their activities to represent our interests in BBB and beyond.
Key Responsibilities in Role:
Project management, Strategic Planning and Execution
Contribute to and refine our organ area strategy for BBB models, and be responsible for communications and activity updates to project teams, development functions, and leadership teams.
Play a key role in aligning overall BBB strategy across Roche and Genentech by coordinating scientific sharing across the REDs. Track and drive progression of adopting these models across functions.
Facilitate partnerships with external collaborators, including academic institutions, consortiums, and CROs to drive NAM science that enables adoption..
Manage external collaborations in the BBB organ area with the above groups, which are a key component of our overall BBB technology strategy. Be responsible for both experimental and logistical requirements for these collaborations, e.g. experimental design, compound requests & shipment, etc.
Laboratory and Scientific Contributions
Act as a central source of knowledge for BBB models used at Genentech, and perform experiments requiring usage of these models to support cross-functional needs, primarily active research & development requests.
Perform training of end-users across internal functions, and provide experimental and scientific support as necessary to aid in model troubleshooting, data interpretation, and development of new assays or models as necessary.
Participate in maintenance of routine laboratory upkeep tasks, such as stocking, coordinating equipment maintenance, cleanouts, etc.
Who You Are:
Ph.D. in biology, bioengineering, biomedical engineering, pharmacology, or a related field with significant experience in in vitro systems; exceptional candidates with equivalent experience will be considered.
1-3+ years of experience in pharmaceutical, biotechnology, or research organizations, with a focus on complex in vitro systems.
Proven experience in developing, qualifying, and applying complex in vitro BBB models in the form of organoids, MPS, or related platforms in a drug discovery or translational research setting.
Prior experience in a project management or strategy-focused role is highly desirable, with demonstrated success in cross-functional collaboration.
Key Skills and Competencies
Project management expertise and impeccable organizational skills, with a demonstrated ability to manage multiple priorities effectively.
Scientific experience and background in blood-brain barrier biology or neurobiology and in vitro modeling.
Strong understanding of the biological underpinnings and applications of complex in vitro systems in drug development.
Team-oriented mindset, with a focus on fostering innovation, collaboration, and driving to impact.
Relocation benefits are not available for this posting.
The expected salary range for this position based on the primary location of California is $121,100.00- $224,900 Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- Ph.D. in biology, bioengineering, biomedical engineering, pharmacology, or a related field, or equivalent experience
- Significant experience with complex in vitro systems
- 1-3+ years of experience in pharmaceutical, biotechnology, or research organizations focused on complex in vitro systems
- Experience developing, qualifying, and applying complex in vitro blood-brain barrier models, including organoids, microphysiological systems, or related platforms
- Experience applying complex in vitro models in drug discovery or translational research
- Project management or strategy-focused experience with demonstrated cross-functional collaboration
- Project management expertise and strong organizational skills
- Scientific background in blood-brain barrier biology or neurobiology and in vitro modeling
- Strong understanding of complex in vitro systems and their applications in drug development
- Strong communication, multitasking, collaboration, and stakeholder-management skills
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
