OPPORTUNITY
Mammoth is currently seeking a creative and detail-oriented Senior Research Associate with experience in next generation sequencing (NGS) and molecular biology to join our NGS Core. The ideal candidate will work collaboratively and cross-functionally with colleagues to develop and execute NGS workflows to support the discovery, characterization, and development of novel Cas nucleases for genome editing.
The successful candidate will also have the opportunity to contribute broadly across technical areas, such as high-throughput screening in mammalian cell lines and molecular biology and genomics process development. This is an excellent career opportunity for researchers who want to learn new skills while contributing to development of cutting-edge CRISPR technologies.
KEY RESPONSIBILITIES
- Help develop and execute in-house NGS workflows, including the following:
- Establish and qualify novel NGS library preparation techniques
- Troubleshooting current NGS library preparations
- Operate and maintain in-house NGS platform
- Timely reporting of data, analysis, or/and status updates
- Execute current NGS-based assays to meet the technical needs across teams
- Detailed, accurate, and timely documentation of experimental procedures, data, and analysis, including meticulous sample tracking and data management
REQUIRED QUALIFICATIONS
- Bachelor’s degree in molecular biology, genome sciences, biochemistry, or a related field
- 2 years of academic/biotechnology industry research or laboratory operations experience
PREFERRED QUALIFICATIONS
- Experience working on custom library preparation using NGS to answer scientific questions
- Experience operating Illumina sequencers in a research or core facility setting
- Experience or proficiency in NGS data analysis
- Experience with both Illumina and Oxford Nanopore platforma
BENEFITS
- Company-paid health/vision/dental benefits
- Unlimited vacation and generous sick time
- Company-sponsored meals and snacks
- Wellness, caregiver and ergonomics benefits
- 401(k) with company matching
Base Salary Range: $ 95,000 - $105,000
Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity.
COMPANY
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.
Top Skills
What We Do
Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to improve lives by reading and writing the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions. By leveraging its internal research and development and exclusive licensing to Cas12, Cas13, Cas14, and CasΦ, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.
