Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays
Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)
Support development and validation of new ADME assays to expand the group’s scientific capabilities
Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)
Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators
Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable
Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions
Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams
Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics
Master's in Lifescience with 7+ years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.
Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles
Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments
Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding
Ability to troubleshoot experimental challenges and apply sound scientific judgment
Self-driven and capable of managing multiple tasks while working within demanding project timelines
Strong attention to detail and commitment to maintaining high scientific and data quality standards
Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams
Strong communication skills for interacting with internal teams, collaborators, and stakeholders
Highly organised with the ability to function effectively in a fast-paced research environment
Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs
A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h
Skills Required
- Master's in Life Sciences with 4-5 years experience
- Ph.D. in Pharmaceutical Sciences, Pharmacology, or related (for Group Leader)
- 10-15 years relevant DMPK/In-Vitro ADME and PK experience (for Group Leader)
- Practical experience with LC-MS/MS and HPLC bioanalytical methods
- Experience developing and validating analytical methods (LC-MS/MS) and complementary detection modalities
- Hands-on experience with in vitro ADME assays (microsomal stability, plasma stability, solubility, permeability, CYP inhibition, plasma protein binding)
- Practical cell culture experience with established cell lines
- Experience processing and analysing data using GraphPad Prism, MS Excel, and mass spectrometry software (e.g., Sciex)
- Experience managing CRO collaborations and outsourced in-vivo PK studies
- Proven leadership, team management, and mentoring experience (for Group Leader)
- Project management skills including budgeting, resource allocation, and reporting
- Strong scientific communication, report writing, and stakeholder presentation skills
- Ability to troubleshoot experiments and maintain high data quality and documentation standards
What We Do
o2h group is a collaborative innovation firm that seeds new ideas in science, technology, and social enterprise. It operates through six symbiotic verticals: o2h discovery (an integrated drug discovery platform), o2h technology (AI and software tools), o2h ventures (seed investment for life science assets), o2h therapeutics (pre-clinical IP), o2h co-work, and o2h community, focusing on co-investing and co-creating to bring innovative assets to life.
