Senior Program Manager

Location Type: Remote (USA) with up to 25% travel

ABOUT FORESIGHT DIAGNOSTICS

Foresight Diagnostics is a molecular diagnostics company pioneering non-invasive cancer detection through highly sensitive, cell-free DNA-based liquid biopsy technologies. Our proprietary methods - originally developed at Stanford University - are designed to detect smaller tumors earlier and enable more personalized treatment strategies for patients with cancer.

We sit at the intersection of molecular biology, bioinformatics, and next-generation sequencing (NGS), and we translate rigorous science into clinically meaningful solutions. Following our acquisition by Natera, we now combine the agility of a mission-driven startup with the scale and resources of a global leader in cell-free DNA testing. It’s an exciting moment to join us.

Headquartered in Boulder, Colorado, our team operates in a high accountability, collaborative environment where quality and continuous improvement aren’t just values - they’re how we work every day.

WHY THIS ROLE EXISTS

The Senior Program Manager will lead complex, cross-functional initiatives supporting operational programs at both the Austin, TX and Boulder, CO sites. Projects and Programs may include operational and site readiness for product and clinical trial launches; initiatives to improve, scale, or automate wet lab and dry lab workflows; and product sustainment and lifecycle management efforts, such as change management for reagent obsolescence, supplier transitions, and integration of vendor-driven software or platform upgrades.

This role owns end-to-end program strategy and execution, aligning stakeholders across laboratory operations, clinical development, R&D, manufacturing, regulatory, quality, software, and external partners. The Senior Program Manager will own, drive, communicate, and engage all project partners to enable accountability, problem solving, and on-time/within-budget delivery for simultaneous projects and programs. Success in this role requires onsite engagement (up to 25% travel) to facilitate rapid decision-making, build alignment, and resolve issues in a highly collaborative, fast-paced setting. This position reports to the Associate Director of Program Management.

WHAT YOU’LL DO

• Own end-to-end delivery of complex operational programs, including scope, schedule, budget, and resource strategy, ensuring alignment with regulatory and business requirements

• Lead cross-functional program execution across laboratory operations, clinical operations, R&D, and external partners to deliver on translational research, clinical, and commercial timelines

• Drive operational readiness initiatives, including laboratory site readiness for product and clinical trial launches, and process implementation across wet lab and dry lab workflows

• Adhere to and facilitate the formal governance processes to communicate program status, risks, dependencies, and trade-offs; escalate issues as needed; and present data-driven recommendations and business proposals to senior leadership to enable timely, informed decision-making

• Develop and maintain program roadmaps, ensuring alignment with organizational priorities and securing stakeholder buy-in

• Extract and refine user needs and requirements from stakeholders and lead teams to focus on the most valuable deliverables.

• Lead risk and issue management, proactively identifying, mitigating, and resolving complex technical and operational challenges

• Ensure adherence to regulated processes, including design controls, change management, and quality system requirements (FDA, CAP/CLIA)

• Drive cross-functional accountability, influencing without direct authority to ensure alignment, ownership, and timely execution

• Partner with Alliance Management and external stakeholders to ensure seamless execution of joint programs and delivery commitments

• Champion continuous improvement throughout the organization, identifying and acting on opportunities to enhance operational efficiency

• Cultivate, build and maintain positive and collaborative relationships with cross-functional teams

WHAT YOU’LL BRING

• 5-7+ years of experience in program management, or equivalent combination of project and program management and relevant functional experience in biotechnology, diagnostics, clinical laboratory, or life sciences

• Experience supporting laboratory operations, clinical operations and trial execution (preferred)

• Background in NGS diagnostics, including assay and software components (MRD experience preferred)

• Strong familiarity with FDA, CAP/CLIA, and design control processes

• PMP or equivalent certification (strongly preferred)

• Proven ability to influence senior stakeholders and drive alignment in matrixed organizations

• Demonstrated success leading complex, cross-functional programs from concept through commercialization

• Strong analytical and operational mindset, with the ability to translate complex data into actionable insights

• Excellent executive communication skills, with the ability to tailor messaging across technical and non-technical audiences

• Experience building and scaling program management tools, frameworks, and governance models

• Proficiency with program management and collaboration tools (e.g., Smartsheet, Jira, Office Timeline, etc.)

• Ability to manage multiple concurrent programs in a fast-paced, high-growth environment

• Situational awareness, coupled with facilitation, problem solving, and conflict resolution skills to drive cross-functional decision-making

• This position may be required to work across time zones as needed to support project schedules

COMPENSATION, BENEFITS & EQUAL OPPORTUNITY

This role offers a competitive annual base compensation of $145,000 - $165,000 commensurate with experience, and a comprehensive benefits package including:

• Medical, dental, and vision

• Flexible PTO and paid holidays

• Parental leave

• 401(k) with company match

You will be working on interesting problems with extremely high impact. We promote the professional development of our teams and encourage upward mobility within the company for high performing employees. Foresight Diagnostics is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Ready to make an impact in cancer diagnostics?

Apply below - we’d love to hear from you.