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The OpportunityThe Technical Development Leader (TDL) is responsible for leading Technical Development Teams (TDTs) in crafting and driving Chemistry, Manufacturing, and Control (CMC) strategies for clinical drug candidates from early human trials through product launch. The TDL ensures successful achievement of TDT goals, effective risk mitigation, and seamless communication across teams and cross-functional collaborators. This role involves comprehensive project planning, scheduling, resourcing, and reporting.
This position requires proven ability to effectively lead teams and work in situations with a high degree of ambiguity and challenges and to solve complex problems/manage highly complex projects.
Major Duties and Responsibilities
Leadership: Lead scientific and technical teams throughout the asset lifecycle, from preclinical development to product launch, ensuring the scientific integrity of the CMC strategy.
Strategy Development & Execution: Develop and implement multifaceted technology strategies essential for product success, including manufacturing processes, drug product and device configurations, supply chains and regulatory submissions.
Enterprise-wide Perspective: Provide strategic insights and ensure customer focus in project deliverables; Maintain regular updates to project teams, senior management, and governance committees, ensuring transparent and informed decision-making.
Innovation: Design novel strategies for licensure of new modalities and efficient development of standard therapeutics, building new company capabilities.
Representation: Represent Pharma Technical functions on asset/lifecycle teams and partner with various team leaders to align CMC strategy with broader goals of the company. May act as a consultant to top executives.
Project Management: Oversee manufacturing and delivery of clinical supplies, manage CMC development costs, and ensure adherence to timelines, milestones and resource forecasts. Anticipate and resolve issues, developing contingency and risk mitigation plans.
Decision-Making: Serve as the primary decision-maker for CMC development, investments, and risk management, employing effective decision-making processes.
The TDL role demands excellent communication, collaboration, strategic and critical thinking, decision-making, negotiating, and influencing skills, along with the ability to lead complex projects and solve intricate problems.
Required:
B.S./M.S/Ph.D. degree in chemistry, pharmaceutics, chemical engineering or related field
10-15+ years of experience in the pharmaceutical industry, with prior experience as a CMC team leader and strong technical knowledge of large molecule process and product development.
Advanced understanding of the drug development process and a history of successful innovation, recognized as a thought leader in CMC/product development.
Preferred:
Program Management: Demonstrated ability to handle complex, cross-functional programs and innovate new ideas and approaches. Ability to work proactively and think strategically. Strong negotiation and decision-making skills.
Collaboration: Effective collaborating with team members and senior management. Successful experience working with third parties.
Communication: Excellent verbal and written communication skills, with a history of influencing others in cross-functional areas.
The expected salary range for this position based on the primary location of South San Francisco, CA is $169,100 to $314,000 (Senior TDL) OR $194,900 to $361,900 (Principal TDL). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are available for this job posting.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Skills Required
- B.S./M.S./Ph.D. in chemistry, pharmaceutics, chemical engineering, or related field
- 10-15+ years pharmaceutical industry experience
- Prior experience as a CMC team leader with strong technical knowledge of large‑molecule process and product development
- Advanced understanding of the drug development process and a history of successful innovation in CMC/product development
- Proven ability to lead teams, manage complex projects, and resolve issues in ambiguous, high‑complexity situations
- Program management experience handling complex, cross‑functional programs
- Experience collaborating with third parties and senior management
- Excellent verbal and written communication and influencing skills
Genentech Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Genentech and has not been reviewed or approved by Genentech.
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Healthcare Strength — Health coverage is described as comprehensive across medical, dental, vision, mental health, and prescriptions, supported by HSAs/FSAs and broad wellness resources. On‑site fitness and health centers, mental‑health clinicians, and specialized programs like fully covered preventive cancer screenings and menopause support deepen the offering.
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Retirement Support — Retirement benefits feature a 401(k) with up to a 4% company match plus an additional annual 6% company contribution to eligible pay. Additional financial protections such as life and accident insurance complement salary, bonuses, and stock options.
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Leave & Time Off Breadth — Time away includes about 20 paid vacation days, paid holidays, personal days, and a year‑end shutdown. A paid six‑week sabbatical every six years notably expands long‑term time‑off flexibility.
Genentech Insights
What We Do
Considered the founder of the industry, Genentech, now a member of the Roche Group, has been delivering on the promise of biotechnology for more than 40 years. Genentech is a biotechnology company dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions. That is why we use cutting-edge science to create and deliver innovative medicines around the globe. To us, science is personal. Making a difference in the lives of millions starts when you make a change in yours.
