Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a Senior Manager, ERP Finance Systems to join its IS&I organization at our Pasadena, CA, San Diego, CA, or Madison, WI sites. This role leads the delivery and continuous improvement of Dynamics 365 Finance & Operations (F&O) capabilities across Finance, Procurement, Accounts Payable and Receivable, Fixed Assets, Project Management Accounting, and Cost Management.
At the Senior Manager level, this individual operates with significant autonomy, serves as the primary IT liaison to Finance and related business functions, and oversees work that may be performed by other team members. They bring deep platform expertise while expanding their focus to include team delivery, vendor governance, process ownership, and stakeholder alignment with executive level business partners. The ideal candidate combines hands-on D365 F&O knowledge with the leadership capability to develop team members, own outcomes end-to-end, and proactively shape how ERP capabilities serve the business.
Responsibilities
Leadership & Team Delivery
- Own end-to-end delivery across ERP Finance workstreams; ensure the team operates with quality, reliability, and adherence to change control and release management standards
- Drive process improvement and operational efficiency within the ERP Finance domain, not just execute existing processes
- Manage project scope, timelines, and resources across concurrent workstreams with limited oversight from above
Stakeholder & Business Partnering
- Serve as the primary IS&I point of contact for Finance and related business functions; build trusted advisor relationships at all levels and especially at the executive level.
- Translate business requirements into functional ERP solutions; facilitate design sessions and solution reviews with business stakeholders independently
- Monitor and communicate emerging Dynamics 365 F&O capabilities, AI advancements, and Microsoft roadmap updates to key business partners with a clear point of view on relevance and impact
- Represent IS&I in cross-functional forums and project steering committees; drive alignment without requiring manager escalation
Domain & Technical Expertise
- Maintain deep subject matter expertise across Dynamics 365 F&O Finance modules including Accounts Payable, Accounts Receivable, Fixed Assets, Project Management Accounting, Cost Management, and Procurement & Sourcing
- Lead architecture and design decisions for new functionality, system integrations, and third-party solutions; ensure designs leverage D365 out-of-the-box capability, Power Platform tools, and best practices
- Serve as primary liaison to third-party vendors for solution integration, evaluation, and ongoing partnership governance
- Provide domain expertise in D365 data modeling; design and oversee Power BI reporting solutions to support Finance operations and decision-making
- Identify software gaps, propose scalable solutions, and ensure the platform roadmap remains aligned to business priorities
Compliance & Risk Management
- Ensure team adherence to regulatory and compliance requirements including Sarbanes-Oxley (SOX), 21 CFR Part 11, and Computer Software Assurance (CSA) processes
- Own compliance posture within the ERP Finance domain; proactively identify risk and drive remediation before issues escalate
- Support internal and external audit activities; serve as the IT subject matter expert for ERP Finance during SOX audit cycles
Requirements
- Bachelor’s degree in Finance, Information Systems, or a related field, or equivalent experience
- 10+ years of hands-on Dynamics 365 F&O functional experience, with demonstrated depth across Finance modules
- Proven experience leading a team or workstream; comfortable with performance management, feedback, and developing others
- Experience managing vendor relationships and third-party integrations end-to-end
- Working knowledge of Agile principles and release management practices
- Experience with Power BI and the Microsoft Power Platform
- Familiarity with Electronic Data Interchange (EDI) and SK Global Treasury Automation Suite
- Strong communication and stakeholder management skills; able to present and drive alignment with Director-level business partners independently
Preferred
- Prior consulting experience in ERP Finance implementations
- SOX audit experience in a hands-on IT or functional capacity
- Life Sciences or Pharma industry background; familiarity with GxP environments
- 21 CFR Part 11 compliance experience
- Experience with Microsoft Copilot for D365 and M365
- Power Platform toolset development experience
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Skills Required
- Bachelor's degree in Finance, Information Systems, or related field, or equivalent experience
- 10+ years of hands-on Dynamics 365 F&O functional experience with depth across Finance modules
- Proven experience leading a team or workstream, including performance management and developing others
- Experience managing vendor relationships and third-party integrations end-to-end
- Working knowledge of Agile principles and release management practices
- Experience with Power BI and the Microsoft Power Platform
- Familiarity with Electronic Data Interchange (EDI) and SK Global Treasury Automation Suite
- Strong communication and stakeholder management skills; able to present and align with Director-level partners independently
- Prior consulting experience in ERP Finance implementations
- SOX audit experience in a hands-on IT or functional capacity
- Life Sciences or Pharma industry background and familiarity with GxP environments
- 21 CFR Part 11 compliance experience
- Experience with Microsoft Copilot for D365 and M365
- Power Platform toolset development experience
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
