Senior Director, Program Management

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. 

Vir Biotechnology has exclusive rights to the universal PRO-XTEN® masking platform for oncology and infectious disease. PRO-XTEN® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.

Vir Biotechnology is seeking an experienced Program Manager to provide senior-level leadership for Development Program Teams, including our Hepatitis Delta program in Phase III and NDA/BLA-enabling activities. In this role, you will partner closely with the Program Executive to lead cross-functional matrix teams responsible for advancing Vir Biotechnology’s mid- to late-stage assets through commercialization and life-cycle management. 

You bring deep pharmaceutical program management experience across the development lifecycle, along with a strong track record of leading cross-functional teams and fostering a culture of high performance, empowerment, and delivery. In this role, you are a confident, adaptable leader who communicates with clarity and respect, builds strong teams, and drives execution. 

This role is based at our San Francisco headquarters, with an expectation of at least three days per week in the office. 

Cross-Functional Leadership and Collaboration

• Partner with the Program Executive to lead the global Program Team and drive strategy and execution for assigned programs
• Partner with Clinical Development sub-team lead and other functional leaders to drive operational execution and integrate sub-team activities into the broader program strategy
• Drive matrix team performance, alignment, and communication through effective leadership and disciplined use of Vir Biotechnology’s tools, processes, and team norms

Timelines and Scenario Planning

• Build, maintain, and govern integrated global cross-functional program timelines that highlight dependencies, milestones, deliverables, decision points, and critical path activities, including developing and supporting portfolio-level timelines as needed
• Partner with Regulatory Affairs, Biostatistics, Clinical Operations, Safety, Translational Medicine, and Commercial to develop and execute integrated development and registration strategies
• Ensure data integrity and accurate reporting across timelines and other team tools and processes to support informed decision-making and reliable inputs for annual budgets, reforecasts, and long-range planning

Strategic Program Planning

• Define program milestones, decision points, inflection points, and deliverables in partnership with the Program Executive and senior leadership and develop scenario-based plans and decision trees
• Communicate with governance committees and functional leaders to address program needs, risks, resource requirements, and recommendations, and help teams navigate organizational decision-making effectively
• Identify and leverage interdependencies across short-, mid-, and long-term program plans, and advise teams on risks and opportunities to accelerate development

Program Activity and Risk Management

• Lead effective meetings and information management by prioritizing the right topics, achieving meeting objectives, communicating decisions and risks to key stakeholders, and ensuring timely completion of action items
• Bridge strategy and execution at the program level by managing risks, aligning diverse disciplines, and navigating complexity

Program Management Excellence

• Drive innovation by identifying opportunities and implementing solutions that improve the efficiency and effectiveness of the PPM function  
• Champion continuous improvement and project management excellence across Vir Biotechnology by contributing to the development and refinement of standard processes, systems, and tools. 

• Bachelor’s degree in a scientific discipline with 18+ years of drug development experience, or an advanced degree (MS, PhD, MBA preferred) with commensurate experience
• Proven success leading high-performing cross-functional teams through the drug development process, ideally including registrational trials and marketing applications (NDA, BLA, MAA) through approval
• Demonstrated experience managing tactical and operational work, including agendas, minutes, and timelines, while also leading strategic discussions across development stages and leadership levels
• Strong technical proficiency with Smartsheet is required, as well as SharePoint site creation and management
• Significant practical experience with project management methodologies, concepts, techniques, and tools is required. PMP certification or advanced project management training is preferred