Senior Director, Program Management – Transformation Office

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Indianapolis, IN
In-Office
152K-222K Annually
Healthtech • Biotech • Pharmaceutical
The Role

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Senior Director, Program Management – Transformation Office, serves as a key strategic leader responsible for orchestrating the design and execution of enterprise-wide transformation programs within the Global Quality organization. This role aligns transformation initiatives with Eli Lilly’s Quality business goals, ensuring value realization across quality, supply chain, manufacturing, digital systems, and compliance functions.

Responsibilities:

  • Strategic Program Leadership: Lead the end-to-end lifecycle of Quality transformation programs, including initiation, planning, execution, monitoring, and closure. Translate strategy into executable program plans with clear outcomes and success metrics.

  • Governance and Stakeholder Alignment: Develop and manage governance structures such as steering committees, dashboards, and review processes. Engage executive stakeholders to ensure alignment, visibility, and accountability for transformation outcomes.

  • Cross-Functional Delivery: Oversee cross-functional teams, manage interdependencies, and resolve obstacles to ensure on-time, on-budget delivery of initiatives. Partner closely with senior leadership across Quality, R&D, Manufacturing, and Commercial to synchronize transformation priorities.

  • Portfolio and Risk Management: Own part of the Quality transformation program portfolio and related performance metrics. Identify and mitigate risks, manage scope, and adjust resources to optimize delivery effectiveness.

  • Change Enablement: Collaborate with Change Management to embed best practices into program delivery. Lead planning and implementation of adoption strategies, training, and readiness assessments to ensure successful organizational integration.

  • Innovation and Continuous Improvement: Champion the adoption of lean, agile, and digital-first methods. Drive continuous improvement of program management capabilities and influence enterprise-wide transformation maturity.

  • Team Leadership and Development: Build and lead a high-performing program team through coaching, talent planning, and development. Foster a culture of accountability, innovation, and excellence in execution.

Basic Requirements:

  • Bachelor’s degree in Business, Engineering, Life Sciences, or related field.

  • 10-12 years of experience in program/project management, with demonstrated success in leading enterprise-wide initiatives.

  • Proven leadership in matrixed, cross-functional environments.

  • Certification in Project Management, such as PMP (Project Management Professional), PMI-ACP, PRINCE2, Certified Scrum Master, AgilePM.

  • Governance, stakeholder alignment, and strategic planning.

  • Cross-functional execution across quality, R&D, and supply chain.

  • Deep knowledge of Quality systems, standards, and operational practices.

  • Digital awareness and change management leadership.

  • Strong executive communications and stakeholder engagement.

  • Strong analytics and expertise driving value realization through strategic decision-making.

Additional Skills/Preferences:

  • MBA, MS in Regulatory Science, Engineering, or Public Health preferred.

  • Experience in regulated environments, preferably pharma or life sciences.

  • Lean Six Sigma certification (Green or Black Belt).

  • Prosci or other change management certification a plus.

  • Experience with digital transformation or smart manufacturing environments.

  • Background across quality, R&D, commercial, or supply chain.

  • Experience using dashboards, analytics tools, and performance reporting frameworks.

Additional Information:

  • Position is located at Lilly Corporate Center, Indianapolis, IN.

  • Primary location is Lilly Corporate Center, Indianapolis, Indiana but consideration can be given for location at existing global Lilly manufacturing site.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$151,500 - $222,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

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The Company
HQ: Indianapolis, IN
39,451 Employees
Year Founded: 1876

What We Do

Eli Lilly and Company engages in the discovery, development, manufacture, and sale of products in pharmaceutical products business segment.

For more than a century, we have stayed true to a core set of values – excellence, integrity, and respect for people – that guide us in all we do: discovering medicines that meet real needs, improving the understanding and management of disease, and giving back to communities through philanthropy and volunteerism.

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