Senior Director, IT

About Terrestrial Bio, Inc.

Terrestrial is transforming the delivery of next-generation therapies, starting with GLP-1.

Terrestrial's proprietary Tacterra™ microarray patch (MAP) and applicator platform consists of a patch resembling an adhesive bandage, which is applied with a preloaded applicator and removed after a few minutes. Once applied, each patch delivers bioactive tips into the skin, which dissolve quickly into the body, rapidly releasing their therapeutic payload. Designed for self-administration, the temperature-stable Tacterra™ platform enables precise, controlled delivery of a wide range of therapeutics without medical sharps or refrigeration.

Terrestrial has generated strong clinical and in-vivo proof of concept across multiple molecules. For more information, visit www.terrestrialbio.com.

Why this role

At Terrestrial Bio, IT is not a shared service. It is a strategic capability that will determine whether a highly regulated, fast-moving manufacturing operation can scale without losing control, compliance, or speed. We are building from scratch. We need a senior leader who can own that build — and then own the function it becomes.

Senior IT leaders rarely get to make every foundational decision. At this stage, you will define the architecture, choose the systems, build the team, and set the operating model — before scale locks those decisions in. You will report to the SVP of Operations with a clear and near-term path to the CFO, reflecting IT’s role as a core business function, not a support cost. This is a VP-track role for the right operator.

The Senior Director of IT will be Terrestrial Bio’s first internal IT executive: responsible for designing, building, and leading the technology infrastructure for a company scaling from 60 to 120+ people across three sites, consolidating into a new headquarters within 18 months — and growing well beyond that.

This is not a maintenance role. This is a build role with an executive mandate.

What you'll do

You will establish the IT function from the ground up and carry it through the company’s next phase of growth. That means:

• Setting IT strategy and architecture in a greenfield, regulated manufacturing environment

• Building and leading the internal IT team — hiring, developing, and retaining talent as the company scales

• Owning the full technology stack: infrastructure, cloud, ERP, SaaS, networking, and security

• Executing a complex site transition — one location to three, then consolidating into a new HQ

• Establishing GxP-compliant IT governance, data integrity frameworks, and audit-readiness

• Serving as the executive IT partner to Manufacturing, Quality, Finance, and Operations

• Managing IT budget, vendors, and contracts with appropriate rigor for a regulated environment

Who you are

• 10+ years in IT, with at least 5 in a senior leadership role

• Demonstrated experience building or standing up an IT function, ideally as first-in-seat

• Deep expertise in infrastructure, cloud architecture, ERP, and enterprise security

• GxP, 21 CFR Part 11, or equivalent regulated-industry IT compliance experience

• Experience managing multi-site environments and major infrastructure transitions

• Has built and led an IT function, not just managed one

• Brings both startup scrappiness and enterprise discipline — and knows when to apply each

• Understands GxP, data integrity, and the compliance expectations of regulated manufacturing

• Can move fluently between infrastructure detail and board-level operational thinking

• Has hired and developed IT teams in high-growth environments

• Is trusted by engineers, operators, quality leaders, and executives alike

Preferred

• Biotech, pharma, or medical device background strongly preferred

• Experience supporting combination-product or device manufacturing a plus

• B.S. in Computer Science, Information Systems, Engineering, or related field

Your impact

Within 12–18 months:

• IT infrastructure deployed, stable, and trusted across all sites

• HQ transition executed without operational disruption

• IT team in place and performing

• GxP-compliant governance and audit-readiness established

• IT operating as a strategic partner — not a reactive support function

• Architecture and systems capable of supporting the next stage of company scale

  Compensation: The anticipated base salary range for this position is $197,000 - $243,000. Actual compensation will be determined based on a variety of factors including experience, qualifications, and internal equity.

  Onsite expectations: The majority of our roles at Terrestrial are either onsite or hybrid, which allows us to meet both business and team needs. Candidates applying must be willing to be onsite 4-5 days per week.

  Location: Woburn, MA and our new, custom facility in Allston MA planned for Q4 of 2026.

  At Terrestrial, we’re bringing together exceptional talent to drive our product development forward. We value collaboration, curiosity, and a dynamic work environment. We aim to recruit, employ, train, compensate and promote regardless of race, religion, color, national origin, sex, gender identity or expression, sexual orientation, disability, age, or veteran status.