Scientist, Statistical and Translational Genomics

About Foresite Labs

Foresite Labs is a translational R&D team that derives insights from precision measurement and population-scale biology and genetics to address unmet clinical needs. We use human genetics to systematically dissect and understand human disease biology and develop and critically evaluate therapeutic hypotheses. We engage in translational research, transforming basic insights into therapeutic opportunities. Our work supports drug discovery and company formation, and provides the core around which new ideas are realized and incubated. We offer competitive salaries, excellent benefits, a flexible work environment, and the opportunity to learn from top thinkers in various disciplines. Foresite Labs is headquartered in San Francisco and Boston. 

Role

We are looking for an applied scientist to join our team to support the generation and testing of therapeutic hypotheses across disease domains. We offer a flexible work environment, a diverse set of projects, and a best-in-class peer group to learn from. This is a great opportunity to tackle a unique set of problems while shaping the future of healthcare. If you have experience in statistical genetics, translational genomics, or genetic epidemiology with an interest in using your skills and experience to understand and improve human health, let’s talk.

Responsibilities

• Perform large-scale human genomic analyses to evaluate therapeutic hypotheses and opportunities across all disease areas.
• Participate in large-scale human genomic discovery collaborations.
• Translate genomic insights into clinically and biologically meaningful results that can support R&D initiative of launched companies and those in incubation.
• Work in close peer-to-peer collaboration with colleagues throughout Foresite Labs and Foresite Capital to identify opportunities for therapeutic translation.
• Interpret and communicate analysis findings to internal and external stakeholders to support decision-making for launched companies and incubation efforts with genomic insights.

Qualifications

Required

• PhD, or expectation to complete a PhD by May 2024, in Human Genetics, Statistical Genetics, Genetic Epidemiology, Biostatistics, or related field.
• Knowledge of genome-wide and phenome-wide analysis approaches, including genotype and sample quality control, phenotype evaluation, imputation, and approaches for well-calibrated association discovery in the presence of cryptic relatedness, population structure, extreme case-control imbalance, and sparse observations.
• Hands-on experience with common and rare variant association analyses in large WES/WGS and GWAS datasets. Familiarity with single- and aggregated variant methods (e.g., burden, SKAT, VT).
• Experience leveraging a broad range of publicly available databases to annotate data/results or supplement results interpretation from statistical analyses. 
• Experience in statistical programming with R, Python, or other programming languages, and with common tools for large-scale analyses.
• Excellent oral and written communication skills. Ability to communicate complex concepts to audiences with a wide range of backgrounds and technical familiarity.
• Ability and desire to work in a fast-paced, interactive, and fluid environment with shifting deadlines and priorities, in a multidisciplinary team focused on therapeutically-relevant genomic discovery. 

Preferred

• Experience in the design, management, and execution of large-scale multi-site collaborative studies and with electronic health record derived phenotypes.
• Experience in polygenic score construction, validation, and application.
• Experience with methods for causal inference.
• Software engineering experience, eg. git, package management and deployment, workflow management systems such as Nextflow or Snakemake, and knowledge of distributed/parallel computation.

Foresite Labs is an equal opportunity employer. We thrive on diversity and collaboration.

Salary range: $130k-150k